ArticleNeurotoxicity research2021
Serum Calcium Predicts Cognitive Decline and Clinical Progression of Alzheimer's Disease.
Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Magnesium and Cognitive Health in Adults: A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2024Pooled it
- Outdoor Air Pollution, Perivascular Space Morphology, and Cognition in Preadolescence.Biological psychiatry global open science · 2026Article
- Blood predictive biomarkers for cognitive impairment among community-dwelling older adults: a cross-sectional study in China.Scientific reports · 2025Article
- Development and internal verification of nomogram for forecasting delirium in the elderly admitted to intensive care units: an analysis of MIMIC-IV database.Frontiers in neurology · 2025Article
- Association between hypertension, diabetes, depression, and serum calcium with the risk of all-cause and vascular dementia: findings from the UK biobank.European journal of nutrition · 2024Article
- The Concurrent Association of Magnesium and Calcium Deficiencies with Cognitive Function in Older Hospitalized Adults.Nutrients · 2024Article
- Essential Nutrients and White Matter Hyperintensities: A Two-Sample Mendelian Randomization Study.Biomedicines · 2024Article
- Targeting calcium signaling in Alzheimer's disease: challenges and promising therapeutic avenues.Neural regeneration research · 2024Article
- Associations between plasma metal elements and risk of cognitive impairment among Chinese older adults.Frontiers in aging neuroscience · 2024Article
- Metals in Alzheimer's Disease.Biomedicines · 2023Review
- There is no evidence that vitamin D supplementation drives the progression of Alzheimer's disease.Aging cell · 2023Article
- Heavy Metals and Essential Metals Are Associated with Cerebrospinal Fluid Biomarkers of Alzheimer's Disease.International journal of molecular sciences · 2022Article
- Association of famine exposure and the serum calcium level in healthy Chinese adults.Frontiers in endocrinology · 2022Article
- An Updated Mendelian Randomization Analysis of the Association Between Serum Calcium Levels and the Risk of Alzheimer's Disease.Frontiers in genetics · 2021Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Relationship between serum calcium and Alzheimer's disease (AD) remains unclear. The aim of this study is to test whether serum calcium is associated with other AD-associated biomarkers and could predict clinical progression in nondemented elders. This was a longitudinal population-based study. The sample was derived from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort, which included 1224 nondemented elders: 413 cognitively normal (CN) and 811 mild cognition impairment (MCI). Associations were investigated between serum calcium and longitudinal changes in Aβ/tau pathologic features, brain structure, cognitive function, and disease progression. Serum calcium concentrations increased with disease severity. Serum calcium predicted longitudinal cognitive decline and conversion from nondemented status to AD dementia (adjusted HR = 1.41, 95% CI 1.13-1.76). Furthermore, serum calcium levels were negatively correlated with CSF-Aβ
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