Evidence map›Paper›PMID 33216281›Full record

ArticleCell and tissue banking2021

Osteogenically-induced exosomes stimulate osteogenesis of human adipose-derived stem cells.

Mengru Zhu, Yang Liu, Hongzhi Qin, Shuang Tong, Qiang Sun, Ting Wang, Hua Zhang, Mengying Cui, Shu Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell and tissue banking, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mengru Zhu *Department of plastic surgery, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, China.
Yang Liu *School of Chemical Engineering, Dalian University of Technology, No. 2 Linggong Road, Dalian, 116024, China.
Hongzhi QinDepartment of plastic surgery, The First Affiliated Hospital of Dalian Medical University, 222 Zhongshan Road, Dalian, 116011, China.
Shuang TongDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China.
Qiang SunDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China.
Ting WangDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China.
Hua ZhangDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China.
Mengying CuiDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China.
Shu GuoDepartment of Plastic surgery, The First affiliated Hospital of China Medical University, No 155 Nanjing North Street, Shenyang, 110002, China. sguo@cmu.edu.cn.

Funding

National Natural Science Foundation of China 31200740National Natural Science Foundation of China 51872332Natural Science Foundation of Liaoning Province 20170541040
6 · The paper itself

Abstract

Exosomes exhibit great therapeutic potential in bone tissue engineering. The study aimed to investigate whether the exosomes derived from human adipose-derived stem cells (hADSCs-Exos) during different time-span of osteogenic differentiation could promote osteogenesis. The appropriate concentrations of hADSCs-Exos to enhance the proliferation, migration and osteogenesis of hADSCs-Exos were also examined. PKH67 labelled hADSCs-Exos was used to detect the internalization ability of hADSCs. The osteogenic differentiation abilities of hADSCs after treatment with hADSCs-Exos was evaluated by Alizarin red staining (ARS). The proliferation and migration of hADSCs was examined by cell counting kit-8 and wound healing assay, respectively. The expression of exosomal surface markers and osteoblast-related protein of hADSCs was assessed by Western blot. PKH67-labelled exosomes were internalized by hADSCs after 4 h incubation. ARS showed that the amount of mineralized nodules in Exo

Indexed as

Adipose TissueExosomesOsteogenesisStem CellsCell DifferentiationCell ProliferationCells, CulturedHumansBone tissue engineeringExosomesHuman adipose-derived stem cellsOsteogenic differentiation

Identifiers

PMID33216281
PMCPMC7864848

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.