Evidence map›Paper›PMID 33216252›Full record

SynthesisCurrent oncology reports2020

Vitamin D in Head and Neck Cancer: a Systematic Review.

Antti Mäkitie, Iida Tuokkola, Göran Laurell, Outi Mäkitie, Kerry Olsen, Robert P Takes, Ewa Florek, Krzysztof Szyfter, Cornelis F M Sier, Alfio Ferlito

Open access · hybridAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Current oncology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 3 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Observational
  6. Article
  7. Article
  8. The vitamin DFrontiers in immunology · 2025
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 5 countries.

Antti MäkitieDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, P. O. Box 263, FI-00029 HUS, Helsinki, Finland. antti.makitie@helsinki.fi.ORCID 0000-0002-0451-2404
Iida TuokkolaDepartment of Otorhinolaryngology-Head and Neck Surgery, Helsinki University Hospital, University of Helsinki, P. O. Box 263, FI-00029 HUS, Helsinki, Finland.
Göran LaurellDepartment of Surgical Sciences, ENT, Uppsala University, SE-75185, Uppsala, Sweden.
Outi MäkitieChildren's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0002-4547-001X
Kerry OlsenDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, MN, USA.
Robert P TakesDepartment of Otolaryngology-Head and Neck Surgery, Radboud University Medical Center, Nijmegen, The Netherlands.ORCID 0000-0003-4784-0499
Ewa FlorekLaboratory of Environmental Research, Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland.ORCID 0000-0002-2689-3009
Krzysztof SzyfterInstitute of Human Genetics, Polish Academy of Sciences, Poznan, Poland.
Cornelis F M SierDepartment of Surgery, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-4337-2758
Alfio FerlitoCoordinator of International Head and Neck Scientific Group, Padua, Italy.
University of Helsinki · FIInstitute of Human Genetics · PLKarolinska University Hospital · SELeiden University Medical Center · NLMayo Clinic · USPoznan University of Medical Sciences · PLRadboud University Nijmegen · NLUppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewObservational studies have shown that serum 25-OH vitamin D [25(OH)D] is inversely associated with overall cancer risk in many malignancies. We performed a systematic literature review to determine whether vitamin D deficiency is related to head and neck cancer (HNC) etiology and outcome. RECENT

findingsThe search yielded five prospective studies reporting 25(OH)D levels prior to cancer diagnosis and their effect on the risk of HNC. Eight studies were cross-sectional or case-control studies, in which 25(OH)D levels were only measured after cancer diagnosis. Two studies found an inverse association between 25(OH)D level and HNC risk, while two other prospective cohort studies demonstrated no connection between 25(OH)D and HNC risk. Several studies reported cancer patients to have significantly lower 25(OH)D levels than controls. Associations between 25(OH)D and prognosis and mortality were variable. The link between vitamin D and HNC has so far only been investigated in a few observational, prospective, and case-control studies. Vitamin D deficiency may be more common in HNC patients than in the healthy population. There is no evidence for a causal relationship. Further studies are needed to evaluate whether low 25(OH)D concentrations play a role in the development or outcome of HNCs.

Indexed as

Head and Neck NeoplasmsHumansVitamin DVitamin D DeficiencyVitamin DCarcinomaDeficiencyEtiologyMalignancyRadiotherapySurgery

Identifiers

PMID33216252
PMCPMC7679336
OpenAlexW3104256595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.