Evidence map›Paper›PMID 33216248›Full record

ReviewMedical oncology (Northwood, London, England)2020

MicroRNAs and target molecules in bladder cancer.

Payam Kheirmand Parizi, Fereshteh Yarahmadi, Hoseins Movahedi Tabar, Zohreh Hosseini, Abdolazim Sarli, Nadia Kia, Alireza Tafazoli, Seyed-Alireza Esmaeili

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. An Overview of Angiogenesis in Bladder Cancer.Current oncology reports · 2023
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Diagnostic panel of serum miR-125b-5p, miR-182-5p, and miR-200c-3p as non-invasive biomarkers for urothelial bladder cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 3 countries.

Payam Kheirmand PariziCellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Fereshteh YarahmadiSchool of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
Hoseins Movahedi TabarSchool of Medicine, Semnan University of Medical Science, Semnan, Iran.
Zohreh HosseiniFaculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran.
Abdolazim SarliDepartment of Medical Genetic, Faculty of Medical Science, Tarbiat Modares University, Tehran, Iran.
Nadia KiaAgostino Gemelli University Hospital, Torvergata University of Medical Sciences, Rome, Italy.
Alireza TafazoliDepartment of Analysis and Bioanalysis of Medicines, Faculty of Pharmacy With the Division of Laboratory Medicine, Medical University of Bialystok, Bialystok, Poland.
Seyed-Alireza EsmaeiliImmunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Imunoman2009@gmail.com.ORCID http://orcid.org/0000-0002-9371-4170
Agostino Gemelli University Polyclinic · ITHamedan University of Medical Sciences · IRIsfahan University of Medical Sciences · IRMashhad University of Medical Sciences · IRMedical University of Białystok · PLSemnan University of Medical Sciences · IRShahid Chamran University of Ahvaz · IRTarbiat Modares University · IR

Funding

H2020 Marie Skłodowska-Curie Actions 754432
6 · The paper itself

Abstract

Bladder cancer (BC) is considered as one of the most common malignant tumors in humans with complex pathogenesis including gene expression variation, protein degradation, and changes in signaling pathways. Many studies on involved miRNAs in BC have demonstrated that they could be used as potential biomarkers in the prognosis, response to treatment, and screening before the cancerous phenotype onset. MicroRNAs (miRNAs) regulate many cellular processes through their different effects on special targets along with modifying signaling pathways, apoptosis, cell growth, and differentiation. The diverse expression of miRNAs in cancerous tissues could mediate procedures leading to the oncogenic or suppressor behavior of certain genes in cancer cells. Since a specific miRNA may have multiple targets, an mRNA could also be regulated by multiple miRNAs which further demonstrates the actual role of miRNAs in cancer. In addition, miRNAs can be utilized as biomarkers in some cancers that cannot be screened in the early stages. Hence, finding blood, urine, or tissue miRNA biomarkers by novel or routine gene expression method could be an essential step in the prognosis and control of cancer. In the present review, we have thoroughly evaluated the recent findings on different miRNAs in BC which can provide comprehensive information on better understanding the role of diverse miRNAs and better decision making regarding the new approaches in the diagnosis, prognosis, prevention, and treatment of BC.

Indexed as

Biomarkers, TumorHumansMicroRNAsPharmacogeneticsUrinary Bladder NeoplasmsBiomarkers, TumorMicroRNAsBiomarkerBladder cancerCancermiRNA

Identifiers

PMID33216248
OpenAlexW3098379854

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.