Evidence map›Paper›PMID 33216235›Full record

ArticleCellular and molecular neurobiology2021

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca

Mizuho Horioka, Emilie Ceraudo, Emily Lorenzen, Thomas P Sakmar, Thomas Huber

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. Article
  5. Therapeutic potential for P2YPurinergic signalling · 2023
    Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Mizuho HoriokaTri-Institutional Program in Chemical Biology, New York, NY, 10065, USA.ORCID http://orcid.org/0000-0003-0947-2744
Emilie CeraudoLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY, USA.ORCID http://orcid.org/0000-0001-6563-9751
Emily LorenzenLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY, USA.ORCID http://orcid.org/0000-0002-0008-0966
Thomas P SakmarLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY, USA. sakmar@mail.rockefeller.edu.ORCID http://orcid.org/0000-0002-2836-8953
Thomas HuberLaboratory of Chemical Biology and Signal Transduction, The Rockefeller University, 1230 York Ave., New York, NY, USA. hubert@rockefeller.edu.ORCID http://orcid.org/0000-0002-1844-262X
Rockefeller University · USTri-Institutional PhD Program in Chemical Biology · US

Funding

Tri-Institutional PhD Program in Chemical BiologyT32GM115327 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI TAN, DEREK S · 2015 to 2019
$741k
NIGMS NIH HHS T32 GM115327NIH HHS T32 GM115327
6 · The paper itself

Abstract

Many G protein-coupled receptors (GPCRs) signal through more than one subtype of heterotrimeric G proteins. For example, the C-C chemokine receptor type 5 (CCR5), which serves as a co-receptor to facilitate cellular entry of human immunodeficiency virus 1 (HIV-1), normally signals through the heterotrimeric G protein, Gi. However, CCR5 also exhibits G protein signaling bias and certain chemokine analogs can cause a switch to Gq pathways to induce Ca

Indexed as

Adenosine TriphosphateCalcium SignalingChemokine CCL5HEK293 CellsHumansPurinergic AgonistsPurinergic AntagonistsReceptor Cross-TalkReceptors, CCR5Receptors, G-Protein-CoupledReceptors, PurinergicSuraminAdenosine TriphosphateCCR5 protein, humanChemokine CCL5Purinergic AgonistsPurinergic AntagonistsReceptors, CCR5Receptors, G-Protein-CoupledReceptors, PurinergicSuraminCCR5ChemokinesCrosstalkGPCR signalingG protein biasPurinergic receptors

Identifiers

PMID33216235
PMCPMC8159800
OpenAlexW3105586445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.