ArticleJournal of neurology2021
Cognitive impairment in temporal lobe epilepsy: contributions of lesion, localization and lateralization.
Article in Journal of neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review.Annals of clinical and translational neurology · 2026Pooled it
- An Interplay Between Post-Traumatic Epilepsy and Associated Cognitive Decline: A Systematic Review.Frontiers in neurology · 2022Pooled it
- Influence of histopathologic type of hippocampal sclerosis on neuropsychological profile.Epilepsia · 2026Article
- Predicting post-surgical visuospatial memory performance in people with drug-resistant epilepsy.Epileptic disorders : international epilepsy journal with videotape · 2026Article
- Evaluating the task-specificity model of verbal memory: Regional volumetric analyses in temporal lobe epilepsy with hippocampal sclerosis.Epilepsia open · 2026Article
- Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment.Neuroimage. Reports · 2026Article
- Bitemporal Lobe Epilepsy: Evolving Diagnostic and Treatment Paradigms.Epilepsy currents · 2026Article
- Bilateral cornu ammonis 3-dominant mechanism of visual working memory impairment in right temporal lobe epilepsy and hippocampal sclerosis.Brain communications · 2026Article
- Examining the Effectiveness of Neuropsychological Interventions on Cognition in Patients with Epilepsy: A Systematic Review and Meta-Analysis.Neuropsychology review · 2025Review
- Support vector machines predict postoperative memory outcomes in temporal lobe epilepsies.Epilepsia open · 2025Article
- Language and Memory Network Alterations in Temporal Lobe Epilepsy: A Functional and Structural Connectivity Study.AJNR. American journal of neuroradiology · 2025Article
- Cognitive Decline in Nasopharyngeal Carcinoma Survivors with Post-Radiation Epilepsy: A Prospective Cohort Study.Cancers · 2025Article
- Can MOCA Be Applied for Rough Cognitive Assessment in Patients with Epilepsy in Mongolia?Journal of clinical medicine · 2025Article
- Nucleus accumbens shell electrical lesion attenuates seizures and gliosis in chronic temporal lobe epilepsy rats.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Unlocking the Potential of Freeze-Dried Broccoli Powder: A Novel Approach to Enhancing Cognitive Resilience in Temporal Lobe Epilepsy.Food science & nutrition · 2025Article
- A novel AAV9-dual microRNA-vector targetingMolecular therapy. Methods & clinical development · 2024Article
- Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis.Acta epileptologica · 2024Article
- Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study.Epilepsia · 2024Article
- Stereoelectroencephalography-Guided Radiofrequency Thermocoagulation: Diagnostic and Therapeutic Implications.Brain sciences · 2024Review
- Chemogenetic inhibition of subicular seizure-activated neurons alleviates cognitive deficit in male mouse epilepsy model.Acta pharmacologica Sinica · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is an important comorbidity of refractory temporal lobe epilepsy (TLE). We aimed to explore the impact of (i) specific lesions, such as dysembryoplastic neuroepithelial tumor (DNET), dysplasia, or hippocampal sclerosis, (ii) focus localization (medial versus lateral) and (iii) focus lateralization (right versus left) on the neuropsychological profile of refractory TLE adult patients.
methodsWe examined the neuropsychological characteristics of 312 adults with refractory TLE: 100 patients without hippocampal sclerosis (HS) and 212 with HS. Scores on tests of intelligence (Global IQ, Verbal IQ and Performance IQ), working memory, episodic memory (verbal and visual learning and forgetting), executive functions and language abilities were analyzed.
resultsThree main factors influenced the neuropsychological profile of refractory TLE patients: (i) the lesion, patients with HS obtaining poorer cognitive performances than patients without HS and specifically DNET patients performing better than patients with HS, (ii) the focus side, that seems only relevant for verbal memory abilities which are affected in left but not right TLE patients and (iii) the localization of seizure focus, patients with medial TLE exhibiting lower memory performances than patients with lateral TLE.
conclusionLesion, localization and lateralization are major contributors of the cognitive impairment depicted in TLE. Hippocampal sclerosis appears as the main contributor.
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