Evidence map›Paper›PMID 33216171›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2021

Effects of resveratrol on the proliferation and osteogenic differentiation of deciduous dental pulp stem cells from neurofibromatosis type 1 patient.

Claudinéia Pereira Maranduba, Gustavo Torres Souza, Antônio Márcio Resende do Carmo, José Marcelo Sallabert de Campos, Nádia Rezende Barbosa Raposo, Marcelo de Olivera Santos, Carlos Magno da Costa Maranduba, Fernando de Sá Silva

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Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Claudinéia Pereira MarandubaLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.
Gustavo Torres SouzaLaboratory of Human Genetics and Cell Therapy, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.
Antônio Márcio Resende do CarmoDepartment of Endodontology, Dentistry School, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.
José Marcelo Sallabert de CamposLaboratory of Genetics, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.
Nádia Rezende Barbosa RaposoCenter of Research and Innovation in Health Sciences (NUPICS), Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil.
Marcelo de Olivera SantosBasic Life Sciences Department, Federal University of Juiz de Fora, Governador Valadares, 35020-670, Brazil.
Carlos Magno da Costa MarandubaLaboratory of Genetics, Biology Department, Biological Sciences Institute, Federal University of Juiz de Fora, Juiz de Fora, 36036-900, Brazil. carlos.maranduba@ufjf.edu.br.ORCID 0000-0001-7327-1934
Fernando de Sá SilvaBasic Life Sciences Department, Federal University of Juiz de Fora, Governador Valadares, 35020-670, Brazil.
Universidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe aimed at verifying whether resveratrol can decrease cell proliferation and change osteogenic differentiation of cells obtained from patients with type 1 neurofibromatosis (NF1).

methodsDeciduous dental pulp derived stem cells were isolated from NF1 patient and healthy volunteer. These cells were subjected to increasing concentrations of resveratrol and evaluated for proliferation and mineralization of osteogenic differentiation.

resultsThe results showed that resveratrol reduced the difference in proliferation between CNT and NF1 cells in a dose-dependent manner and this property was more prominent in affected cells than in healthy cells. Resveratrol showed no statistically significant changes in mineralization in osteogenic differentiation of NF1 cells, at low doses tested.

conclusionsIn conclusion, in a dose-dependent manner, resveratrol displays interesting properties that could be applied in a possible treatment aimed at decreasing cellular proliferation in neurofibromatosis. Furthermore, it is selective concerning healthy cells and not affecting cell differentiation. Further research to cell selectivity, differentiation to other tissue types, and cell cytotoxicity are needed.

Indexed as

Neurofibromatosis 1OsteogenesisCell DifferentiationCell ProliferationCells, CulturedDental PulpHumansResveratrolStem CellsResveratrolDeciduous dental pulp stem cellsNeurofibromatosisOsteogenic differentiationProliferationResveratrolStem cells

Identifiers

PMID33216171
OpenAlexW3101382731

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.