ArticleJournal of molecular evolution2021
Revisiting the Relationships Between Genomic G + C Content, RNA Secondary Structures, and Optimal Growth Temperature.
Article in Journal of molecular evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Genomic and evolutionary factors influencing the prediction accuracy of optimal growth temperature in prokaryotes.mSystems · 2026Article
- Comparative genomics of crucian carp-isolatedFrontiers in microbiology · 2026Article
- Compression rates of microbial genomes are associated with genome size and base composition.Genomics & informatics · 2024Article
- Genomics-based identification of a cold adapted clade in Deinococcus.BMC biology · 2024Article
- Comparative genomics of thermosynechococcaceae and thermostichaceae: insights into codon usage bias.Acta biochimica Polonica · 2024Article
- Analysis of codon usage patterns in complete plastomes of four medicinalFrontiers in genetics · 2024Article
- Taxonomic identification and temperature stress tolerance mechanisms of Aequorivita marisscotiae sp. nov.Communications biology · 2023Article
- Ribosomal proteins can hold a more accurate record of bacterial thermal adaptation compared to rRNA.Nucleic acids research · 2023Article
- Main Factors Shaping Amino Acid Usage Across Evolution.Journal of molecular evolution · 2023Review
- A simple stochastic model describing the evolution of genomic GC content in asexually reproducing organisms.Scientific reports · 2022Article
- Article
- Comparative Analysis of Codon Bias in the Chloroplast Genomes of Theaceae Species.Frontiers in genetics · 2022Article
- Genome-wide alignment-free phylogenetic distance estimation under a no strand-bias model.Bioinformatics advances · 2022Article
- Thermal adaptation of mRNA secondary structure: stability versus lability.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Journal of Molecular Evolution Turns 50.Journal of molecular evolution · 2021Article
- Review
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Abstract
Over twenty years ago Galtier and Lobry published a manuscript entitled "Relationships between Genomic G + C Content, RNA Secondary Structure, and Optimal Growth Temperature" in the Journal of Molecular Evolution that showcased the lack of a relationship between genomic G + C content and optimal growth temperature (OGT) in a set of about 200 prokaryotes. Galtier and Lobry also assessed the relationship between RNA secondary structures (rRNA stems, tRNAs) and OGT, and in this case a clear relationship emerged. Increasing structured RNA G + C content (particularly in regions that are double-stranded) correlates with increased OGT. Both of these fundamental relationships have withstood test of many additional sequences and spawned a variety of different applications that include prediction of OGT from rRNA sequence and computational ncRNA identification approaches. In this work, I present the motivation behind Galtier and Lobry's original paper and the larger questions addressed by the work, how these questions have evolved over the last two decades, and the impact of Galtier and Lobry's manuscript in fields beyond these questions.
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