Evidence map›Paper›PMID 33216042›Full record

ArticleJournal of Parkinson's disease2021

Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.

Samuel J Crowley, Guita Banan, Manish Amin, Jared J Tanner, Loren Hizel, Peter Nguyen, Babette Brumback, Katie Rodriguez, Nikolaus McFarland, Dawn Bowers and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Samuel J CrowleyDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Guita BananDepartment of Biochemistry and Molecular Biology, Gainesville, FL, USA.
Manish AminDepartment of Biochemistry and Molecular Biology, Gainesville, FL, USA.
Jared J TannerDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Loren HizelDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Peter NguyenDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Babette BrumbackDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Katie RodriguezDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Nikolaus McFarlandDepartment of Neurology, Gainesville, FL, USA.
Dawn BowersDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Mingzhou DingMcKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Thomas A MareciDepartment of Biochemistry and Molecular Biology, Gainesville, FL, USA.
Catherine C PriceDepartment of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
University of Florida · USUniversity of Florida Health · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
White Matter Connectivity and PD Cognitive PhenotypesR01NS082386 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2013 to 2017
$2.3M
White Matter and Cognition in Parkinson's DiseaseK23NS060660 · NINDS · UNIVERSITY OF FLORIDA · PI PRICE, CATHERINE E · 2007 to 2011
$619k
NCATS NIH HHS UL1 TR001427NINDS NIH HHS K23 NS060660NINDS NIH HHS R01 NS082386NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

backgroundSome individuals with Parkinson's disease (PD) experience working memory and inhibitory difficulties, others learning and memory difficulties, while some only minimal to no cognitive deficits for many years.

objectiveTo statistically derive PD executive and memory phenotypes, and compare PD phenotypes on disease and demographic variables, vascular risk factors, and specific neuroimaging variables with known associations to executive and memory function relative to non-PD peers.

methodsNon-demented individuals with PD (n = 116) and non-PD peers (n = 62) were recruited to complete neuropsychology measures, blood draw, and structural magnetic resonance imaging. Tests representing the cognitive domains of interest (4 executive function, 3 memory) were included in a k-means cluster analysis comprised of the PD participants. Resulting clusters were compared demographic and disease-related variables, vascular risk markers, gray/white regions of interest, and white matter connectivity between known regions involved in executive and memory functions (dorsolateral prefrontal cortices to caudate nuclei; entorhinal cortices to hippocampi).

resultsClusters showed: 1) PD Executive, n = 25; 2) PD Memory, n = 35; 3) PD Cognitively Well; n = 56. Even after disease variable corrections, PD Executive had less subcortical gray matter, white matter, and fewer bilateral dorsolateral-prefrontal cortex to caudate nucleus connections; PD Memory showed bilaterally reduced entorhinal-hippocampal connections. PD Cognitively Well showed only reduced putamen volume and right entorhinal cortex to hippocampi connections relative to non-PD peers. Groups did not statistically differ on cortical integrity measures or cerebrovascular disease markers.

conclusionPD cognitive phenotypes showed different structural gray and white matter patterns. We discuss data relative to phenotype demographics, cognitive patterns, and structural brain profiles.

Indexed as

AgedCerebral CortexCluster AnalysisCognitive DysfunctionExecutive FunctionFemaleGray MatterHumansMagnetic Resonance ImagingMaleMemory DisordersMiddle AgedParkinson DiseasePhenotypeWhite MatterdementiaEntorhinal cortexexecutive functionhippocampusmemoryprefrontal cortexwhite matter

Identifiers

PMID33216042
PMCPMC7870551
OpenAlexW3103870686

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.