ArticleJournal of Alzheimer's disease : JAD2021
Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging.
Article in Journal of Alzheimer's disease : JAD, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Physical Activity and Cognitive Decline Among Older Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Walking to protect against cognitive decline: the role of APOE genotype and sex.Biology of sex differences · 2026Article
- Patterns of Factors in the National Institute on Aging Health Disparities Research Framework Domains and Mild Cognitive Impairment Risk.AJPM focus · 2025Article
- Development of Modified Japanese Versions of Questionnaires to Assess Physical and Cognitively Stimulating Activities.JMA journal · 2025Article
- Physical activity and the outcome of cognitive trajectory: a machine learning approach.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Late-life physical activity, midlife-to-late-life activity patterns, APOE ε4 genotype, and cognitive impairment among Chinese older adults: a population-based observational study.The international journal of behavioral nutrition and physical activity · 2025Observational
- Effects of MicroRNAs and Long Non-coding RNAs on Beneficial Action of Exercise on Cognition in Degenerative Diseases: A Review.Molecular neurobiology · 2025Review
- Impact of physical activity on disability-free and disabled life expectancies in middle-aged and older adults: Data from the healthy aging longitudinal study in Taiwan.Geriatrics & gerontology international · 2024Article
- Can integration of Alzheimer's plasma biomarkers with MRI, cardiovascular, genetics, and lifestyle measures improve cognition prediction?Brain communications · 2024Article
- Association between exercise habits in adolescence and old age and the risk of mild cognitive impairment: the Bunkyo health study.Frontiers in aging neuroscience · 2024Article
- Sex-difference in the association between social drinking, structural brain aging and cognitive function in older individuals free of cognitive impairment.Frontiers in psychiatry · 2024Article
- Effect of isotemporal substitution of sedentary behavior with different intensities of physical activity on the muscle function of older adults in the context of a medical center.BMC geriatrics · 2023Article
- Cognitive Function, and Its Relationships with Comorbidities, Physical Activity, and Muscular Strength in Korean Older Adults.Behavioral sciences (Basel, Switzerland) · 2023Article
- Association between physical activity and longitudinal change in body mass index in middle-aged and older adults.BMC public health · 2023Article
- Long-term Cognitive Trajectory After Total Joint Arthroplasty.JAMA network open · 2022Article
- Relationships among young adult general cognitive ability, midlife physical activity, and early late-life cognitive functioning: A four-decade longitudinal cohort study in men.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about the association between physical activity (PA) and cognitive trajectories in older adults.
objectiveTo examine the association between PA and change in memory, language, attention, visuospatial skills, and global cognition, and a potential impact of sex or Apolipoprotein E (APOE) ɛ4 status.
methodsLongitudinal study derived from the population-based Mayo Clinic Study of Aging, including 2,060 cognitively unimpaired males and females aged ≥70 years. Engagement in midlife (ages 50-65) and late-life (last year) PA was assessed using a questionnaire. Neuropsychological testing was done every 15 months (mean follow-up 5.8 years). We ran linear mixed-effect models to examine whether mid- or late-life PA at three intensities (mild, moderate, vigorous) was associated with cognitive z-scores.
resultsLight intensity midlife PA was associated with less decline in memory function compared to the no-PA reference group (time x light PA; estimate [standard error] 0.047 [0.016], p = 0.004). Vigorous late-life PA was associated with less decline in language (0.033 [0.015], p = 0.030), attention (0.032 [0.017], p = 0.050), and global cognition (0.039 [0.016], p = 0.012). Females who were physically inactive in midlife experienced more pronounced cognitive decline than females physically active in midlife and males regardless of PA (p-values for time interaction terms with midlife PA levels and sex were all p < 0.05 for global cognition). APOE ɛ4 carriership did not moderate the association between PA and cognition.
conclusionEngaging in PA, particularly of vigorous intensity in late-life, was associated with less pronounced decline in global and domain-specific cognition. This association may differ by sex.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.