Evidence map›Paper›PMID 33215327›Full record

ArticleJournal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology2020

Unraveling neuroHIV in the Presence of Substance Use Disorders.

Yu Lin, Johnny J He, Roger Sorensen, Linda Chang

Abstract read
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In one paragraph

Article in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yu LinDivision of Neuroscience and Behavior, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Johnny J HeDepartment of Microbiology and Immunology, Chicago Medical School, and Center for Cancer Cell Biology, Immunology and Infection, Rosalind Franklin University, North Chicago, IL, USA.
Roger SorensenDivision of Neuroscience and Behavior, National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Linda ChangDepartment of Diagnostic Radiology and Nuclear Medicine, and Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA. lchang@som.umaryland.edu.ORCID 0000-0002-1267-0699

Funding

Neural Correlates of Working Memory Training For HIV PatientsR01DA035659 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI CHANG, LINDA · 2012 to 2017
$2.8M
HIV Infection and Latency In AstrocytesR01DA043162 · NIDA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI HE, JOHNNY J · 2016 to 2020
$2.8M
miR-132, a new player in HIV/neuroAIDSR01NS094108 · NINDS · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI HE, JOHNNY J · 2015 to 2019
$2.7M
NIDA NIH HHS R01 DA035659NIDA NIH HHS R01DA035659NIDA NIH HHS R01 DA043162NIDA NIH HHS R01DA043162NIDA NIH HHS R01NS094108NINDS NIH HHS R01 NS094108
6 · The paper itself

Abstract

This special issue contains 10 invited review papers that highlighted and extended the presentations at the NIDA-sponsored workshop "Unraveling NeuroAIDS in the Presence of Substance Use Disorders" at the 25th Society on NeuroImmune Pharmacology conference in 2019. The topics covered by these papers focused on the interactive, additive or synergistic effects of substance use disorders (SUD) with HIV infection on the immune system and on neuropathogenesis. These papers reviewed four categories of substances of abuse (opioids, tobacco, stimulants, and cannabis) and how comorbid HIV infection (including models with HIV proteins, HIV transgenic rodent models and SIV) might further impact the dysregulated dopaminergic and immune systems, and the subsequent neuropathogenesis and behavioral disorders known as HIV-associated neurological disorders (HAND). These reviews provided detailed background knowledge regarding how each of these addictive substances and HIV individually or collectively affected the immune system at the cellular, molecular and system levels, and the subsequent clinical and behavioral outcomes. The authors also identified gaps, confounds or constraints in the current disease models and approaches, and proposed future research directions.

Indexed as

Congresses as TopicAIDS Dementia ComplexHIV InfectionsHumansSubstance-Related DisordersSystematic Reviews as TopicHIVHIV persistenceImmune activationImmunopathogenesisNeuropathogenesisSubstance use disordersViral-host interaction

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.