Evidence map›Paper›PMID 33215323›Full record

ReviewHeart failure reviews2021

Psychological stress in heart failure: a potentially actionable disease modifier.

Kristie M Harris, Daniel L Jacoby, Rachel Lampert, Richard J Soucier, Matthew M Burg

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heart failure reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 43 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Well-Known and Novel Behavioural Risk Factors for Heart Failure.Journal of cardiovascular development and disease · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Living Near Contamination: The Impacts on Personal Well-Being.Applied research in quality of life · 2025
    Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Kristie M HarrisYale School of Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine, New Haven, CT, USA. kristie.harris@yale.edu.ORCID 0000-0003-3378-7017
Daniel L JacobyYale School of Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine, New Haven, CT, USA.ORCID 0000-0002-9182-275X
Rachel LampertYale School of Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine, New Haven, CT, USA.ORCID 0000-0003-3313-0939
Richard J SoucierSaint Francis Hospital and Medical Center, Trinity Health of New England, Hartford, CT, USA.ORCID 0000-0003-1966-2082
Matthew M BurgYale School of Medicine, Department of Internal Medicine, Section of Cardiovascular Medicine, New Haven, CT, USA.ORCID 0000-0002-1263-2385
Yale University · USTrinity Health · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Exercise in Genetic Cardiovascular ConditionsR01HL125918 · NHLBI · YALE UNIVERSITY · PI ACKERMAN, MICHAEL JOHN, DAY, SHARLENE M · 2015 to 2019
$4.8M
Stress and Congestive Heart Failure: A mechanistic clinical trialR01HL152548 · NHLBI · YALE UNIVERSITY · PI BURG, MATTHEW M, LAMPERT, RACHEL · 2020 to 2024
$3.6M
Stress, Sleep, and Arterial StiffnessR01HL126770 · NHLBI · YALE UNIVERSITY · PI BURG, MATTHEW M · 2016 to 2019
$3.3M
PTSD, Sleep, and Risk for Incident HypertensionR01HL125587 · NHLBI · YALE UNIVERSITY · PI BURG, MATTHEW M · 2015 to 2018
$3.2M
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS R01 HL125587NHLBI NIH HHS R01 HL125918NHLBI NIH HHS R01 HL126770NHLBI NIH HHS R01 HL152548
6 · The paper itself

Abstract

Psychological stress is common in patients with heart failure, due in part to the complexities of effective disease self-management and progressively worsening functional limitations, including frequent symptom exacerbations and hospitalizations. Emerging evidence suggests that heart failure patients who experience higher levels of stress may have a more burdensome disease course, with diminished quality of life and increased risk for adverse events, and that multiple behavioral and pathophysiological pathways are involved. Furthermore, the reduced quality of life associated with heart failure can serve as a life stressor for many patients. The purpose of this review is to summarize the current state of the science concerning psychological stress in patients with heart failure and to discuss potential pathways responsible for the observed effects. Key knowledge gaps are also outlined, including the need to understand patterns of exposure to various heart failure-related and daily life stressors and their associated effects on heart failure symptoms and pathophysiology, to identify patient subgroups at increased risk for stress exposure and disease-related consequences, and the effect of stress specifically for patients who have heart failure with preserved ejection fraction. Stress is a potentially modifiable factor, and addressing these gaps and advancing the science of stress in heart failure is likely to yield important insights about actionable pathways for improving patient quality of life and outcomes.

Indexed as

Heart FailureQuality of LifeHospitalizationHumansStress, PsychologicalStroke VolumeBehavioralHeart failureMentalPsychologicalStress

Identifiers

PMID33215323
PMCPMC8026548
OpenAlexW3100054257

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.