Evidence map›Paper›PMID 33215308›Full record

ArticleAmino acids2020

Synthesis, in vitro biological activity, hydrolytic stability and docking of new analogs of BIM-23052 containing halogenated amino acids.

Dancho Danalev, Desislava Borisova, Spaska Yaneva, Maya Georgieva, Anelia Balacheva, Tatyana Dzimbova, Ivan Iliev, Tamara Pajpanova, Zdravka Zaharieva, Ivan Givechev and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Amino acids, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Dancho DanalevBiotechnology Department, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Desislava BorisovaDepartment of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Spaska YanevaDepartment of Fundamental of Chemical Technology, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Maya GeorgievaInstitute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Sofia, Bulgaria.
Anelia BalachevaInstitute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Sofia, Bulgaria.
Tatyana DzimbovaInstitute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Sofia, Bulgaria.
Ivan IlievInstitute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Acad. G. Bonchev str., bl. 25, 1113, Sofia, Bulgaria.
Tamara PajpanovaInstitute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Sofia, Bulgaria.
Zdravka ZaharievaBiotechnology Department, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Ivan GivechevBiotechnology Department, University of Chemical Technology and Metallurgy, Sofia, Bulgaria.
Emilia NaydenovaDepartment of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, Bulgaria. e_naydenova@abv.bg.ORCID http://orcid.org/0000-0002-2999-5094
Bulgarian Academy of Sciences · BGUniversity of Chemical Technology and Metallurgy · BGElectronics Testing Center · TWSouth-West University "Neofit Rilski" · BG

Funding

Bulgarian National Fund of Scientific Research at the Ministry of Education and Science. DN 19/17, 20.12.2017.
6 · The paper itself

Abstract

One of the potent somatostatin analogs, BIM-23052 (DC-23-99) D-Phe-Phe-Phe-D-Trp-Lys-Thr-Phe-Thr-NH

Indexed as

Amino AcidsAmino Acid SequenceAnimalsBreast NeoplasmsCell Line, TumorCell ProliferationFemaleHep G2 CellsHumansHydrolysisMolecular Docking SimulationOligopeptidesSomatostatinStructure-Activity RelationshipAmino AcidsBIM 23052Oligopeptidesphenylalanyl-phenylalanyl-phenylalanineSomatostatinAnalogs of BIM-23052Cytotoxic effectsDockingHydrolytic stabilityPeptidesSolid-phase peptide synthesisSomatostatin

Identifiers

PMID33215308
OpenAlexW3103778936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.