Evidence map›Paper›PMID 33215259›Full record

ArticleApplied microbiology and biotechnology2021

1-(4-Amino-2-hydroxyphenyl)ethanone from Phomopsis liquidambari showed quorum sensing inhibitory activity against Pseudomonas aeruginosa.

Jin-Wei Zhou, Ai-Qun Jia, Huan Jiang, Pei-Li Li, Hong Chen, Xiao-Juan Tan, En-Qi Liu

Abstract read
PubMed Publisher
In one paragraph

Article in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

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  14. Inactivation ofFrontiers in microbiology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Jin-Wei ZhouSchool of Food and Biology Engineering, Xuzhou University of Technology, Xuzhou, 221018, China.
Ai-Qun JiaSchool of Life and Pharmaceutical Sciences, State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou, 570228, China. jiaaiqun@gmail.com.ORCID http://orcid.org/0000-0002-8089-6200
Huan JiangSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Pei-Li LiSchool of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, 210094, China.
Hong ChenLuoyang Key Laboratory of Organic Functional Molecules, College of Food and Drug, Luoyang Normal University, Luoyang, 471934, China.
Xiao-Juan TanAnhui Provincial Key Laboratory of Molecular Enzymology and Mechanism of Major Diseases, Anhui Normal University, Wuhu, 241000, China. xjtan@ahnu.edu.cn.
En-Qi LiuSchool of Food and Biology Engineering, Xuzhou University of Technology, Xuzhou, 221018, China. leq@xzit.edu.cn.
Nanjing University of Science and Technology · CNXuzhou University of Technology · CNAnhui Normal University · CNHainan University · CNLuoyang Normal University · CN

Funding

Cultivation Fund of Xuzhou University of Technology 00700001Jiangsu Provincial Key Research and Development Program (CN) 2017YFD0201401Research Starting Fund of Xuzhou University of Technology 02900142the National Natural Science Foundation of China 32000091the National Natural Science Foundation of China 41766006
6 · The paper itself

Abstract

Phomopsis liquidambari S47 is an endophytic fungus isolated from the leaves of Punica granatum. Here, we are the first to report a quorum sensing (QS) inhibitor 1-(4-amino-2-hydroxyphenyl)ethanone (AHE) isolated and identified from the metabolites of P. liquidambari S47. Exposure to AHE at sub-MIC concentrations notably suppressed the secretion of acyl-homoserine lactones and virulence factors in Pseudomonas aeruginosa PAO1. To investigate the metabolic variations of P. aeruginosa PAO1 exposed to AHE, magnetic resonance imaging-based metabolomic analysis was performed. AHE treatment created a disturbance in the QS system by suppressing the expressions of QS-related genes. The disturbed QS system resulted in the inhibited activity of antioxidant enzymes and thus enhanced oxidative stress. The vegetable infection assay showed that the virulence of P. aeroginosa PAO1 was attenuated which could be due to the impacts to the amino acid and nucleotide metabolism by enhanced oxidative stress. These findings suggest that AHE has a potential to become an antivirulence "agent" to tackle P. aeruginosa infection. KEY POINTS: • AHE treatment inhibited AHL secretion and virulence factors production. • AHE treatment aggravated oxidative stress and disturbed metabolism. • AHE suppressed QS-related gene expressions and reduced virulence of P. aeruginosa.

Indexed as

AntibiosisPhomopsisPseudomonas aeruginosaQuorum SensingAnti-Bacterial AgentsBacterial ProteinsBiofilmsVirulenceVirulence FactorsAnti-Bacterial AgentsBacterial ProteinsVirulence Factors1-(4-Amino-2-hydroxyphenyl)ethanoneMetabolomicsPseudomonas aeruginosaQuorum sensingVirulence

Identifiers

PMID33215259
OpenAlexW3106146186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.