SynthesisHernia : the journal of hernias and abdominal wall surgery2021
Prehabilitation of complex ventral hernia patients with Botulinum: a systematic review of the quantifiable effects of Botulinum.
Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Metabolism, Morphology and Function of the Anterior Abdominal Wall Musculature in Ventral Hernias and After Repair: A Narrative Review and Research Agenda.Journal of personalized medicine · 2026Review
- Electromyographic and tomographic muscle changes after botulinum toxin administration through either 3 or 8 injection points in patients with large midline ventral hernias: a superiority study.Hernia : the journal of hernias and abdominal wall surgery · 2026Article
- Review
- Long-Term Outcomes of Preoperative Botulinum Toxin Use in Abdominal Wall Reconstruction: A Propensity-Matched Analysis of More Than 5000 Patients Over 5 Years.Aesthetic surgery journal. Open forum · 2026Article
- Multimodal Prehabilitation for Hernia Repair: Linking Metabolic Modulation and Mechanical Methods.Biomedicines · 2025Review
- Follow-up of complex hernia repair with intraoperative fascial traction.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Does sarcopenia have a negative impact on the efficacy of botulinum toxin A in the prehabilitation of patients undergoing incisional hernia repair? A multicentric retrospective study.Hernia : the journal of hernias and abdominal wall surgery · 2025Article
- Exploring Psychological Prehabilitation in Complex Abdominal Wall Reconstruction: A Prospective Pilot Study.Journal of abdominal wall surgery : JAWS · 2025Article
- Review
- [The use of botulinum toxin in hernia surgery: results of a survey in certified hernia centers].Chirurgie (Heidelberg, Germany) · 2024Article
- Achieving fascial closure with preoperative botulinum toxin injections in abdominal wall reconstruction: outcomes from a high-volume center.Updates in surgery · 2024Article
- Prevention of component separation in complex abdominal wall surgery by Botox prehabilitation: a propensity-matched study.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- [Loss of domain and reduction in median suture tension].Chirurgie (Heidelberg, Germany) · 2024Review
- STAPLED FASCIAL CLOSURE VS. CONTINUOUS HAND-SEWN SUTURE: EXPERIMENTAL STUDY OF THE ABDOMINAL WALL ON PORCINE MODEL AND HUMAN CADAVER.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2024Article
- Tanaka score predicts surgical intensive care admission following abdominal wall reconstruction.Hernia : the journal of hernias and abdominal wall surgery · 2022Article
- Assessing Textbook Outcome After Implementation of Transversus Abdominis Release in a Regional Hospital.Journal of abdominal wall surgery : JAWS · 2022Article
- The Use of Botulinum Toxin in Complex Hernia Surgery: Achieving a Sense of Closure.Frontiers in surgery · 2021Review
- Botulinum Toxin in the Surgical Treatment of Complex Abdominal Hernias: A Surgical Anatomy Approach, Current Evidence and Outcomes.In vivo (Athens, Greece)Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeComplex ventral hernia repair (CVHR) encompasses patient optimization, primary fascial closure (PFC), mesh reinforcement and component separation technique (CST), if needed. High rates of complications after CST are still reported. Prehabilitation by managing pre-operative modifiable risk factors, like abdominal wall compliance, possibly reduces these rates. Compliance can be modified by intramuscular injection of Botulinum in the lateral abdominal wall muscles (LAWM). Paralysis leads to elongation of these muscles, which may facilitate PFC and/or prevent CST. Evidence to use Botulinum in hernia patients is scarce and fragmented. An update of evidence for the effect of Botulinum is presented.
methodsA multi-database search was conducted for Botulinum studies in ventral hernia patients. A systematic review was performed to describe its primary effect on compliance (LAWM elongation) and secondary effects like PFC ± CST rate, complications and recurrence.
results14 studies were included (377 patients) with a HDW of median 12 (10-15) cm. A typical intervention consisted of 200-300 U Botulinum in 3 points per hemi-abdomen under US guidance, > 2 weeks pre-operatively and evaluated by CT just before the operation. The primary effect was a median LAWM elongation of 4.0 cm per side without complications of the injection (four studies, 107 patients). The median PFC rate was 100%, CST rate 38%, wound-related complications 19%, medical complications 18% and recurrence 0% (14 studies).
conclusionBotulinum safely elongates the abdominal wall muscles, but the level of evidence available remains low. Any patient in whom PFC is expected to be difficult, could be a candidate for prehabilitation with Botulinum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.