Evidence map›Paper›PMID 33215220›Full record

ArticleMolecular medicine reports2021

Exogenous sodium hydrosulfide protects against high glucose‑induced injury and inflammation in human umbilical vein endothelial cells by inhibiting necroptosis via the p38 MAPK signaling pathway.

Jiaqiong Lin, Xiaoyong Li, Yan Lin, Zena Huang, Wen Wu

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Hydrogen Sulfide (HPathogens (Basel, Switzerland) · 2025
    Article
  3. Recent advances in the role of gasotransmitters in necroptosis.Apoptosis : an international journal on programmed cell death · 2025
    Review
  4. Review
  5. Article
  6. Protective Role of HDiabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  7. Cell death in atherosclerosis.Cell cycle (Georgetown, Tex.) · 2024
    Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Jiaqiong Lin *Department of Endocrinology, Guangdong Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.
Xiaoyong Li *Department of Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Yan Lin *Department of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.
Zena HuangDepartment of General Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.
Wen WuDepartment of Endocrinology, Guangdong Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, P.R. China.
Guangdong Academy of Medical Sciences · CNGuangzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years hydrogen sulfide (H

Indexed as

Human Umbilical Vein Endothelial CellsInflammationMAP Kinase Signaling SystemNecroptosisProtective AgentsSulfidesCells, CulturedCell SurvivalDiabetic AngiopathiesGlucoseHumansInterleukin-1betaInterleukin-6Interleukin-8Membrane Potential, Mitochondrialp38 Mitogen-Activated Protein KinasesCXCL8 protein, humanGlucoseIL1B protein, humanIL6 protein, humanInterleukin-1betaInterleukin-6Interleukin-8p38 Mitogen-Activated Protein KinasesProtective AgentsReactive Oxygen SpeciesReceptor-Interacting Protein Serine-Threonine KinasesRIPK3 protein, humansodium bisulfideSulfidesTNF protein, humanTumor Necrosis Factor-alphahuman umbilical vein endothelial cellshyperglycemianecroptosisp38 MAPKsodium hydrosulfide

Identifiers

PMID33215220
PMCPMC7716414
OpenAlexW3103188767

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.