ArticleGigaScience2020
Localized effect of treated wastewater effluent on the resistome of an urban watershed.
Article in GigaScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Hydrodynamics Shape Antibiotic Resistance in Wastewater-Impacted River Biofilms.Microbial ecology · 2026Article
- Environmental and Health Care Personnel Sampling and Unobserved Clostridium difficile Transmission in ICU.JAMA network open · 2025Observational
- The spread of antimicrobial resistance in the aquatic environment from faecal pollution: a scoping review of a multifaceted issue.Environmental monitoring and assessment · 2025Article
- Prevalence of Antimicrobial ResistantInternational journal of environmental research and public health · 2024Article
- Disentangling abiotic and biotic effects of treated wastewater on stream biofilm resistomes enables the discovery of a new planctomycete beta-lactamase.Microbiome · 2024Article
- Microbial community differentiation in vent chimneys of the Lost City Hydrothermal Field reflects habitat heterogeneity.Frontiers in microbiomes · 2024Article
- Bacterial diversity and chemical ecology of natural product-producing bacteria from Great Salt Lake sediment.ISME communications · 2024Article
- Metagenome mining and functional analysis reveal oxidized guanine DNA repair at the Lost City Hydrothermal Field.PloS one · 2024Article
- Bacterial Diversity and Chemical Ecology of Natural Product-Producing Bacteria from Great Salt Lake Sediment.bioRxiv : the preprint server for biology · 2023Article
- Antimicrobial Resistance Linked to Septic System Contamination in the Indiana Lake Michigan Watershed.Antibiotics (Basel, Switzerland) · 2023Article
- Diversity of enterobacterales in sediments of lagoons with fish farming activity and analysis of antibiotic resistance.Toxicology reports · 2023Article
- Metabolic Strategies Shared by Basement Residents of the Lost City Hydrothermal Field.Applied and environmental microbiology · 2022Article
- The CDC response to antibiotic and antifungal resistance in the environment.Med (New York, N.Y.) · 2021Article
- Localized effect of treated wastewater effluent on the resistome of an urban watershed.GigaScience · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWastewater treatment is an essential tool for maintaining water quality in urban environments. While the treatment of wastewater can remove most bacterial cells, some will inevitably survive treatment to be released into natural environments. Previous studies have investigated antibiotic resistance within wastewater treatment plants, but few studies have explored how a river's complete set of antibiotic resistance genes (the "resistome") is affected by the release of treated effluent into surface waters.
resultsHere we used high-throughput, deep metagenomic sequencing to investigate the effect of treated wastewater effluent on the resistome of an urban river and the downstream distribution of effluent-associated antibiotic resistance genes and mobile genetic elements. Treated effluent release was found to be associated with increased abundance and diversity of antibiotic resistance genes and mobile genetic elements. The impact of wastewater discharge on the river's resistome diminished with increasing distance from effluent discharge points. The resistome at river locations that were not immediately downstream from any wastewater discharge points was dominated by a single integron carrying genes associated with resistance to sulfonamides and quaternary ammonium compounds.
conclusionsOur study documents variations in the resistome of an urban watershed from headwaters to a major confluence in an urban center. Greater abundances and diversity of antibiotic resistance genes are associated with human fecal contamination in river surface water, but the fecal contamination effect seems to be localized, with little measurable effect in downstream waters. The diverse composition of antibiotic resistance genes throughout the watershed suggests the influence of multiple environmental and biological factors.
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