Evidence map›Paper›PMID 33215094›Full record

ArticleBone & joint open2020

Systematic review assessing the evidence for the use of stem cells in fracture healing.

Andrew Mott, Alex Mitchell, Catriona McDaid, Melissa Harden, Rachael Grupping, Alexandra Dean, Ailish Byrne, Laura Doherty, Hemant Sharma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone & joint open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrew MottYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0001-7844-9033
Alex MitchellYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0001-9311-2092
Catriona McDaidYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0002-3751-7260
Melissa HardenCentre for Reviews and Dissemination, University of York, York, UK.ORCID https://orcid.org/0000-0003-2338-6869
Rachael GruppingDepartment of Trauma and Orthopaedics, Hull University Teaching Hospitals, Hull, UK.
Alexandra DeanYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0003-4711-5609
Ailish ByrneYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0001-5656-5674
Laura DohertyYork Trials Unit, Department of Health Sciences, University of York, York, UK.ORCID https://orcid.org/0000-0001-5310-5808
Hemant SharmaDepartment of Trauma and Orthopaedics, Hull University Teaching Hospitals, Hull, UK.ORCID https://orcid.org/0000-0003-3781-1651

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsBone demonstrates good healing capacity, with a variety of strategies being utilized to enhance this healing. One potential strategy that has been suggested is the use of stem cells to accelerate healing.

methodsThe following databases were searched: MEDLINE, CENTRAL, EMBASE, Cochrane Database of Systematic Reviews, WHO-ICTRP, ClinicalTrials.gov, as well as reference checking of included studies. The inclusion criteria for the study were: population (any adults who have sustained a fracture, not including those with pre-existing bone defects); intervention (use of stem cells from any source in the fracture site by any mechanism); and control (fracture healing without the use of stem cells). Studies without a comparator were also included. The outcome was any reported outcomes. The study design was randomized controlled trials, non-randomized or observational studies, and case series.

resultsIn all, 94 eligible studies were identified. The clinical and methodological aspects of the studies were too heterogeneous for a meta-analysis to be undertaken. A narrative synthesis examined study characteristics, stem cell methods (source, aspiration, concentration, and application) and outcomes.

conclusionInsufficient high-quality evidence is available to determine the efficacy of stem cells for fracture healing. The studies were heterogeneous in population, methods, and outcomes. Work to address these issues and establish standards for future research should be undertaken.Cite this article:

Indexed as

Fracturestem cellssystematic review

Identifiers

PMID33215094
PMCPMC7659646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.