ArticleFrontiers in oncology2020
Prognostic Values of Preoperative Inflammatory and Nutritional Markers for Colorectal Cancer.
Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Lower Preoperative Skeletal Muscle Index in Patients with Pathological T4 Colorectal Cancer: An Exploratory Retrospective Cohort Study.Medical sciences (Basel, Switzerland) · 2026Observational
- Machine learning-based preoperative classification of colorectal cancer stage using systemic inflammatory and nutritional biomarkers.BMC gastroenterology · 2026Article
- Prognostic Value of Albumin-to-CEA Ratio in Metastatic Colorectal Cancer: A Retrospective Study.Biomedicines · 2026Article
- Albumin and neutrophil combined prognostic grade for predicting overall survival in colorectal cancer: a retrospective cohort study.Frontiers in oncology · 2026Article
- Early host adaptation defined by nutritional and inflammatory dynamics predicts disease progression in solid tumours.American journal of cancer research · 2026Article
- Integrating nutritional and immune-inflammation-based index predicts disease-free survival of colorectal cancer patients undergoing radical surgery.Journal of gastrointestinal oncology · 2025Article
- Prognostic impact of inflammatory and nutritional markers in colorectal cancer patients with peritoneal metastasis.World journal of gastrointestinal oncology · 2025Article
- Optimal cutpoint of preoperative neutrophil-lymphocyte ratio and associated postoperative prognosis in colorectal cancer patients.International journal of colorectal disease · 2025Article
- Development and Validation of a Nomogram Incorporating Nutritional and Lipid Metabolism Indices to Predict Survival in Non-Small Cell Lung Cancer Patients with Malignant Pleural Effusion.Cancer management and research · 2025Article
- Validated nomograms for non-metastatic colorectal cancer prognosis prediction: a population-based study.Frontiers in oncology · 2025Article
- [Predictive Value of Prognostic Nutritional Index in Prognosis and Spontaneous Pleurodesis of Patients with Advanced Non-small Cell Lung Cancer and Malignant Pleural Effusion].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024Article
- Increased Kremen2 predicts worse prognosis in colon cancer.Pathology oncology research : POR · 2023Article
- Development and validation of a web-based predictive model for preoperative diagnosis of localized colorectal cancer and colorectal adenoma.Frontiers in oncology · 2023Article
- Article
- Novel Signatures Based on the Lymphocyte-to-C-Reactive Protein Ratio Predict the Prognosis of Patients with Early Breast Cancer: A Retrospective Study.Journal of inflammation research · 2022Article
- A Novel Prognostic Model and Practical Nomogram for Predicting the Outcomes of Colorectal Cancer: Based on Tumor Biomarkers and Log Odds of Positive Lymph Node Scheme.Frontiers in oncology · 2021Article
- DNM1: A Prognostic Biomarker Associated with Immune Infiltration in Colon Cancer-A Study Based on TCGA Database.BioMed research international · 2021Article
- Novel Molecular Subtypes and Related Score Based on Histone Acetylation Modification in Renal Clear Cell Carcinoma.Frontiers in cell and developmental biology · 2021Article
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing evidence indicates that inflammation and nutritional status are associated with survival outcomes in patients with colorectal cancer (CRC). This study aimed to investigate the prognostic values of preoperative inflammatory and nutritional factors and develop a prognostic model individually predicting overall survival (OS) and disease-free survival (DFS) in patients with CRC.
methodsWe retrospectively collected data on patients with CRC who underwent radical surgery. Independent prognostic inflammatory and nutritional markers were identified and novel prognostic models were developed incorporating the identified factors. The discriminative ability and model-fitting performance were evaluated by receiver operating characteristic curves and Akaike information criteria. Clinical usefulness was assessed by decision curve analysis.
resultsA total of 400 eligible patients were identified. Multivariate analysis identified pN stage, tumor differentiation grade, neutrophil count, and body mass index as independent prognostic factors for OS, and pN stage, tumor differentiation grade, neutrophil count, neutrophil-lymphocyte ratio, and serum albumin as prognostic factors for DFS. The combined inflammatory and nutritional prognostic model showed better discriminative ability, model-fitting performance, and net benefits than the inflammatory and nutritional models alone, and the American Joint Committee on Cancer (AJCC) 8th TNM classification for predicting OS and DFS.
conclusionPreoperative nutritional and inflammatory factors have significant prognostic value in patients with CRC. A novel prognostic model incorporating preoperative inflammatory and nutritional markers provides better prognostic performance than the AJCC 8th TNM classification. A novel nomogram incorporating preoperative inflammatory and nutritional markers can individually predict OS and DFS in patients with CRC.
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