ReviewPediatric gastroenterology, hepatology & nutrition2020
Differential Diagnosis of Acute Liver Failure in Children: A Systematic Review.
Review in Pediatric gastroenterology, hepatology & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characterization of a Hepatitis Outbreak in Children, 2021 to 2022.JAMA network open · 2022Pooled it
- The incidence, frequency of late liver-related complications, and transplant likelihood in pediatric acute liver failure in Californian children.Hepatology communications · 2026Article
- Fulminant Hepatitis Due to Enterovirus E25 Systemic Infection in a Pediatric Patient.Pathogens (Basel, Switzerland) · 2026Article
- Spontaneous Recovery from Hepatitis A-Induced Acute Liver Failure in a Child: A Rare Case Report from Hargeisa Group Hospital, Somaliland.International medical case reports journal · 2026Article
- Pediatric acute liver failure: Current perspective in etiology and management.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024Review
- Pediatric Acute Liver Failure.Pediatric reports · 2023Article
- Orchestrated regulation of immune inflammation with cell therapy in pediatric acute liver injury.Frontiers in immunology · 2023Review
- Nutritional Support in Acute Liver Failure.Diseases (Basel, Switzerland) · 2022Review
- Prognostic factors and scoring systems associated with outcome in pediatric acute liver failure.BMC pediatrics · 2022Article
- Hepatitis of unknown etiology in children: What we know and what we can do?Frontiers in microbiology · 2022Review
- Paracetamol use during pregnancy - a call for precautionary action.Nature reviews. Endocrinology · 2021Review
- A Case Series on Genotype and Outcome of Liver Transplantation in Children with Niemann-Pick Disease Type C.Children (Basel, Switzerland) · 2021Article
- Male-Dominant Hepatitis A Outbreak Observed among Non-HIV-Infected Persons in the Northern Part of Tokyo, Japan.Viruses · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo develop a probability-based differential diagnosis for pediatric acute liver failure (PALF) based on age and socioeconomic status of the country of origin.
methodsComprehensive literature search using PubMed, EMBASE, and SCOPUS databases was performed. Children 0-22 years of age who met PALF registry criteria were included. Articles included >10 children, and could not be a case report, review article, or editorial. No language filter was utilized, but an English abstract was required. Etiology of PALF, age of child, and country of origin was extracted from included articles.
results32 full text articles were reviewed in detail; 2,982 children were included. The top diagnosis of PALF in developed countries was acetaminophen toxicity (9.24%; 95% CredI 7.99-10.6), whereas in developing countries it was Hepatitis A (28.9%; 95% CredI 26.3-31.7). In developed countries, the leading diagnosis of PALF in children aged <1 year was metabolic disorder (17.2%; 95% CredI 10.3-25.5), whereas in developing countries it was unspecified infection (39.3%; CredI 27.6-51.8). In developed countries, the leading diagnosis in children aged >1 year was Non-A-B-C Hepatitis (8.18%; CredI 5.28-11.7), whereas in developing countries it was Hepatitis A (32.4%; CredI 28.6-36.3).
conclusionThe leading causes of PALF in children aged 0-22 years differ depending on the age and developmental status of their country of origin, suggesting that these factors must be considered in the evaluation of children with PALF.
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Registered trials
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