ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2020
Pediatric Scurvy: How an Old Disease Is Becoming a New Problem.
Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Vitamin/mineral/micronutrient supplement for autism spectrum disorders: a research survey.BMC pediatrics · 2022Trial
- Scurvy Masquerading as Malignancy: A Diagnostic Challenge in a Child With Severe Selective Eating.Cureus · 2026Article
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- Scurvy as a Cause of Leg Pain and Limp in Pediatric and Adolescent Patients.Journal of the Pediatric Orthopaedic Society of North America · 2025Review
- Scurvy, a not obsolete disorder: Clinical report in eight young children and literature review.Open medicine (Warsaw, Poland) · 2025Review
- The Impact of Vitamin Deficiencies on Oral Manifestations in Children.Dentistry journal · 2024Review
- Unusual Presentation of Pediatric Scurvy: A Necrotic Gastrostomy Tube Site in a 14-Year-Old Boy.The American journal of case reports · 2023Article
- Children with Inability to Walk: Don't Forget to Rule Out Scurvy.Indian journal of pediatrics · 2022Article
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- A Narrative Review on Pediatric Scurvy: The Last Twenty Years.Nutrients · 2022Review
- Scurvy mimicking as systemic lupus erythematosus.BMJ case reports · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ascorbic acid (vitamin C) functions as a cofactor and antioxidant within the human body that enables tissue growth and repair, but vitamin C is not intrinsically produced. Scurvy, or ascorbic acid deficiency, has traditionally been viewed as a historical disease. With the incidence of autism spectrum disorder and food restriction on the rise, children's hospitals may see increasing cases of scurvy. This is a single-center, retrospective case series including patients aged 7 to 14 years who were admitted to the Kentucky Children's Hospital with scurvy in the 2018-2019 period. Although selective or restricted eating is not an uncommon behavior among children, especially toddlers, parents of autistic children frequently report their children to be exceedingly selective eaters. However, there currently are conflicting findings on whether this leads to nutritional inadequacy. Although no guidelines exist for the treatment of scurvy, the mainstay of therapy is reintroduction of vitamin C. Oral therapy is generally preferred, but vitamin C can be given parenterally when necessary. In conclusion, oral aversion is a symptom commonly seen in patients with autism spectrum disorder and other developmental delays, potentially leading to increased cases of scurvy. Treatment of scurvy includes reintroduction of vitamin C into the diet. However, oral supplementation may pose unique challenges in this patient population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.