Evidence map›Paper›PMID 33214778›Full record

ReviewThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2020

Sedative and Analgesic Pharmacokinetics During Pediatric ECMO.

Kanecia O Zimmerman, Samantha H Dallefeld, Christoph P Hornik, Kevin M Watt

Open access · greenAbstract readReview
In one paragraph

Review in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Kanecia O ZimmermanDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (KOZ, CPH).
Samantha H DallefeldPediatric Critical Care Medicine, Dell Children's Medical Center of Central Texas, Austin, TX (SHD).
Christoph P HornikDuke Clinical Research Institute, Duke University School of Medicine, Durham, NC (KOZ, CPH).
Kevin M WattDivision of Clinical Pharmacology, University of Utah School of Medicine, Salt Lake City, UT (KMW).
Clinical Research Institute · USDell Children's Medical Center of Central Texas · USUniversity of Utah · US

Funding

Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
UNC-Duke Collaborative Clinical Pharmacology Postdoctoral Training Program-Evaluation SupplementT32GM086330 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KIM L.R. BROUWER, Daniel Gonzalez · 2011 to 2026
$8.5M
Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary DysplasiaR33HL147833 · NHLBI · DUKE UNIVERSITY · PI HORNIK, CHRISTOPH, LAUGHON, MATTHEW · 2021 to 2023
$6.8M
Global Pediatric Clinical Trials NetworkU18FD006298 · FDA · DUKE UNIVERSITY · PI COHEN-WOLKOWIEZ, MICHAEL, HORNIK, CHRISTOPH · 2017 to 2021
$5.5M
Duke CTSA (Composite)KL2TR001115 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, KRAFT, MONICA · 2013 to 2017
$5.1M
Physiologically-Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life SupportR01HD097775 · NICHD · UNIVERSITY OF UTAH · PI WATT, KEVIN M · 2019 to 2023
$2.7M
Safety of Sildenafil in Premature Infants at Risk of Bronchopulmonary DysplasiaR01FD006099 · FDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAUGHON, MATTHEW · 2018 to 2022
$2.0M
Clinical Outcome Assessments for Acute Pain Therapeutics in Infants and young Children (COA APTIC)UG3FD006797 · FDA · DUKE UNIVERSITY · PI REEVE, BRYCE B, ZIMMERMAN, KANECIA OBIE · 2019 to 2019
$1.4M
Safety of Sildenafil in Premature Infants with Severe Bronchopulmonary DysplasiaR61HL147833 · NHLBI · DUKE UNIVERSITY · PI HORNIK, CHRISTOPH, LAUGHON, MATTHEW · 2019 to 2020
$775k
Pharmacokinetics, Pharmacodynamics, and Safety of Methylprednisolone in Neonates on Cardiopulmonary BypassK23HD090239 · NICHD · DUKE UNIVERSITY · PI HORNIK, CHRISTOPH · 2017 to 2020
$646k
Physiologically Based Pharmacokinetics in Critically Ill ChildrenK23HD075891 · NICHD · DUKE UNIVERSITY · PI WATT, KEVIN M · 2014 to 2018
$638k
Investigating polypharmacy-related adverse events in critically ill children using electronic health records and simulated drug levelsK23HD091398 · NICHD · DUKE UNIVERSITY · PI ZIMMERMAN, KANECIA OBIE · 2017 to 2020
$629k
FDA HHS R01 FD006099FDA HHS U18 FD006298FDA HHS UG3 FD006797NCATS NIH HHS KL2 TR001115NHLBI NIH HHS R33 HL147833NHLBI NIH HHS R61 HL147833NICHD NIH HHS HHSN275201000003CNICHD NIH HHS HHSN275201000003INICHD NIH HHS HHSN275201800003INICHD NIH HHS K12 HD047349NICHD NIH HHS K23 HD075891NICHD NIH HHS K23 HD090239NICHD NIH HHS K23 HD091398NICHD NIH HHS R01 HD097775NIGMS NIH HHS T32 GM086330Wellcome Trust
6 · The paper itself

Abstract

Sedatives and analgesics are often administered to critically ill children supported by extracorporeal membrane oxygenation (ECMO) to facilitate comfort and to decrease risks of life-threatening complications. Optimization of sedative and analgesic dosing is necessary to achieve desired therapeutic benefits and must consider interactions between the circuit and patient that may affect drug metabolism, clearance, and impact on target organs. This paper reviews existing

Indexed as

childdeep sedationextracorporeal membrane oxygenationinfantnewbornpain managementpharmacokinetics

Identifiers

PMID33214778
PMCPMC7671016
OpenAlexW3105639278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.