ArticleScientific reports2020
EpOMEs act as immune suppressors in a lepidopteran insect, Spodoptera exigua.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Renaming the 'OS-D/CSP' Family (Part 2): '4-Cysteine Soluble Proteins' (4CSPs)-Intracellular Functions.Insects · 2026Review
- Chemical Modifications of an Insect Immune Resolvin, EpOME, to a Broad-Spectrum Lepidopteran-Specific Insecticide.Insects · 2026Article
- Comparative proteomics provides Insights into activation of jasmonic acid-mediated resistance mechanism in chickpea-Helicoverpa armigera interaction.Plant cell reports · 2026Article
- Insect Lipids: Structure, Classification and Function.Advances in experimental medicine and biology · 2026Review
- Functional Division of Insect Blood Cells by Single-Cell RNA-Sequencing and Cell-Type-Specific FISH Markers.Cells · 2025Article
- Wild-type and resistance-breaking strains of tomato spotted wilt virus differentially upregulate the immunosuppressive epoxyoctadecamonoenoic acid biosynthesis of its insect vector,The Journal of general virology · 2025Article
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- Insect immune resolution with EpOME/DiHOME and its dysregulation by their analogs leading to pathogen hypersensitivity.Insect biochemistry and molecular biology · 2024Article
- Four phospholipase AScientific reports · 2024Article
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- Lipids as a key element of insect defense systems.Frontiers in genetics · 2023Review
- Identification of four secretory phospholipase AFrontiers in endocrinology · 2023Article
- Parasitic nematode secreted phospholipase AFrontiers in immunology · 2023Article
- Effects of Arbuscular Mycorrhizal Fungi-ColonizedInsects · 2022Article
- Intestinal metabolomics of juvenile lenok (Brachymystax lenok) in response to heat stress.Fish physiology and biochemistry · 2022Article
- Cold tolerance strategies of the fall armyworm, Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae).Scientific reports · 2022Article
- Parasitic nematode fatty acid- and retinol-binding proteins compromise host immunity by interfering with host lipid signaling pathways.PLoS pathogens · 2021Article
- Detecting the Conspecific: Herbivory-Induced Olfactory Cues in the Fall Armyworm (Lepidoptera: Noctuidae).Metabolites · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Epoxyoctadecamonoenoic acids (EpOMEs) are epoxide derivatives of linoleic acid (9,12-octadecadienoic acid) and include 9,10-EpOME and 12,13-EpOME. They are synthesized by cytochrome P450 monooxygenases (CYPs) and degraded by soluble epoxide hydrolase (sEH). Although EpOMEs are well known to play crucial roles in mediating various physiological processes in mammals, their role is not well understood in insects. This study chemically identified their presence in insect tissues: 941.8 pg/g of 9,10-EpOME and 2,198.3 pg/g of 12,13-EpOME in fat body of a lepidopteran insect, Spodoptera exigua. Injection of 9,10-EpOME or 12,13-EpOME into larvae suppressed the cellular immune responses induced by bacterial challenge. EpOME treatment also suppressed the expression of antimicrobial peptide (AMP) genes. Among 139 S. exigua CYPs, an ortholog (SE51385) to human EpOME synthase was predicted and its expression was highly inducible upon bacterial challenge. RNA interference (RNAi) of SE51385 prevented down-regulation of immune responses at a late stage (> 24 h) following bacterial challenge. A soluble epoxide hydrolase (Se-sEH) of S. exigua was predicted and showed specific expression in all development stages and in different larval tissues. Furthermore, its expression levels were highly enhanced by bacterial challenge in different tissues. RNAi reduction of Se-sEH interfered with hemocyte-spreading behavior, nodule formation, and AMP expression. To support the immune association of EpOMEs, urea-based sEH inhibitors were screened to assess their inhibitory activities against cellular and humoral immune responses of S. exigua. 12-(3-adamantan-1-yl-ureido) dodecanoic acid (AUDA) was highly potent in suppressing the immune responses. The addition of AUDA to a pathogenic bacterium significantly increased bacterial pathogenicity by suppressing host immune defense. In sum, this study demonstrated that EpOMEs play a crucial role in facilitating anti-inflammatory responses in S. exigua.
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