Evidence map›Paper›PMID 33214612›Full record

ArticleScientific reports2020

A serological assay to detect SARS-CoV-2 antibodies in at-home collected finger-prick dried blood spots.

Donna Grace Karp, Kenneth Danh, Noemi Fonseca Espinoza, David Seftel, Peter V Robinson, Cheng-Ting Tsai

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.

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  18. Diagnostic performance of the SARS-CoV-2 S1RBD IgG ELISA (ImmunoDiagnostics) for the quantitative detection of SARS-CoV-2 antibodies on dried blood spots.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Donna Grace KarpEnable Biosciences Inc., South San Francisco, CA, USA.
Kenneth DanhEnable Biosciences Inc., South San Francisco, CA, USA.
Noemi Fonseca EspinozaEnable Biosciences Inc., South San Francisco, CA, USA.
David SeftelEnable Biosciences Inc., South San Francisco, CA, USA.
Peter V RobinsonEnable Biosciences Inc., South San Francisco, CA, USA. peter@enablebiosciences.com.
Cheng-Ting TsaiEnable Biosciences Inc., South San Francisco, CA, USA. jasontsai@enablebiosciences.com.
Enable Biosciences (United States) · US

Funding

Multiplex food allergy diagnostic based on IgE immunologic markersR44AI141118 · NIAID · ENABLE BIOSCIENCES, INC. · PI SEFTEL, DAVID · 2020 to 2021
$1.5M
Multiplex food allergy diagnostic based on IgE immunologic markersR43AI141118 · NIAID · ENABLE BIOSCIENCES, INC. · PI SEFTEL, DAVID · 2018 to 2018
$224k
NIAID NIH HHS R43 AI141118NIAID NIH HHS R44 AI141118NIH SBIR 2R44DK110005-02NIH SBIR 2RAI141118-02
6 · The paper itself

Abstract

Accurate surveillance of coronavirus disease 2019 (COVID-19) incidence requires large-scale testing of the population. Current testing methods require in-person collection of biospecimens by a healthcare worker, limiting access of individuals who do not have access to testing facilities while placing both patients and healthcare workers at risk of exposure to infection. We report the development and validation of a at-home finger-prick dried blood spot collection kit and an analysis method. We demonstrated 100% sensitivity and specificity using at-home collected specimens across the US. Such methods may facilitate the conduct of unbiased serosurveys within hard to reach populations and help reduce the sample collection burden of serological testing on both health care systems and individuals alike.

Indexed as

AdultAgedAged, 80 and overCOVID-19 Serological TestingDried Blood Spot TestingFemaleHumansMaleMiddle AgedReagent Kits, DiagnosticSensitivity and SpecificityReagent Kits, Diagnostic

Identifiers

PMID33214612
PMCPMC7678827
OpenAlexW3103811394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.