Evidence map›Paper›PMID 33214316›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Entopeduncular Nucleus Projections to the Lateral Habenula Contribute to Cocaine Avoidance.

Hao Li, Maya Eid, Dominika Pullmann, Ying S Chao, Alen A Thomas, Thomas C Jhou

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
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  5. Pallidothalamic Circuit-Selective Manipulation Ameliorates Motor Symptoms in a Rat Model of Parkinsonian.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Article
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  8. Article
  9. Article
  10. Synaptic Adaptations at the Rostromedial Tegmental Nucleus Underlie Individual Differences in Cocaine Avoidance Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hao LiDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
Maya EidDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
Dominika PullmannDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
Ying S ChaoDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
Alen A ThomasDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425.
Thomas C JhouDepartment of Neuroscience, Medical University of South Carolina, Charleston, SC, 29425 jhou@musc.edu.ORCID 0000-0001-8811-0156
Medical University of South Carolina · USSalk Institute for Biological Studies · US

Funding

Cocaine-Conditioned Avoidance Behavior, Mechanisms and Relevance for Drug-SeekingR01DA037327 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JHOU, THOMAS C · 2014 to 2018
$1.7M
Neural Mechanism by which Punishment Modulates Drug-SeekingR21DA032898 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JHOU, THOMAS C · 2012 to 2013
$398k
Opposing Roles of Distinct Output Projections From Prefrontal CortexR21DA037744 · NIDA · TEXAS A&M UNIVERSITY · PI SMITH, RACHEL J · 2014 to 2015
$368k
NIDA NIH HHS R01 DA037327NIDA NIH HHS R21 DA032898NIDA NIH HHS R21 DA037744
6 · The paper itself

Abstract

The aversive properties associated with drugs of abuse influence both the development of addiction and relapse. Cocaine produces strong aversive effects after rewarding effects wear off, accompanied by increased firing in the lateral habenula (LHb) that contributes to downstream activation of the rostromedial tegmental nucleus (RMTg). However, the sources of this LHb activation are unknown, as the LHb receives many excitatory inputs whose contributions to cocaine aversion remain uncharacterized. Using cFos activation and

Indexed as

AnimalsAvoidance LearningCocaineCocaine-Related DisordersElectrophysiological PhenomenaEntopeduncular NucleusHabenulaMaleNeural PathwaysProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleyRewardVentral Tegmental AreaCocaineProto-Oncogene Proteins c-fosaddictionavoidancecocaineentopeduncular nucleuslateral habenularostromedial tegmental nucleus

Identifiers

PMID33214316
PMCPMC7810656
OpenAlexW3102116681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.