Evidence map›Paper›PMID 33214315›Full record

ArticleeNeuro

Sex-Specific Role for Dopamine Receptor D2 in Dorsal Raphe Serotonergic Neuron Modulation of Defensive Acoustic Startle and Dominance Behavior.

Krissy A Lyon, Benjamin D Rood, Lorna Wu, Rebecca A Senft, Lisa V Goodrich, Susan M Dymecki

Open access · goldAbstract read
In one paragraph

Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Auditory processing in rodent models of autism: a systematic review.Journal of neurodevelopmental disorders · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Krissy A LyonDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-4453-8406
Benjamin D RoodDepartment of Genetics, Harvard Medical School, Boston, MA 02115.
Lorna WuDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.
Rebecca A SenftDepartment of Genetics, Harvard Medical School, Boston, MA 02115.ORCID 0000-0003-0081-4170
Lisa V GoodrichDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-3331-8600
Susan M DymeckiDepartment of Genetics, Harvard Medical School, Boston, MA 02115 dymecki@genetics.med.harvard.edu.ORCID 0000-0003-0910-9881
Harvard University · US

Funding

Developmental gene networks of 5HT neurons in addiction, aggression, and anxietyR01DA034022 · NIDA · HARVARD MEDICAL SCHOOL · PI DYMECKI, SUSAN M. · 2014 to 2018
$3.0M
Afferent-efferent interactions in the developing cochleaR01DC015974 · NIDCD · HARVARD MEDICAL SCHOOL · PI GOODRICH, LISA · 2017 to 2021
$2.4M
Circuits, Serotonergic Neurons, and the Modulation of Behavior: Characterization of a Specialized Serotonergic Neuron Subtype Responsive to Dopamine and Central to Social BehaviorK00NS108515 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI LYON, KRISTINE ANNE · 2021 to 2024
$339k
Circuits, serotonergic neurons, and the modulation of behavior: Characterization of a specialized serotonergic neuron subtype responsive to dopamine and central to social behaviorF99NS108515 · NINDS · HARVARD UNIVERSITY · PI LYON, KRISTINE ANNE · 2018 to 2020
$93k
NIDA NIH HHS R01 DA034022NIDCD NIH HHS R01 DC015974NINDS NIH HHS F99 NS108515NINDS NIH HHS K00 NS108515
6 · The paper itself

Abstract

Brain networks underlying states of social and sensory alertness are normally adaptive, influenced by serotonin and dopamine (DA), and abnormal in neuropsychiatric disorders, often with sex-specific manifestations. Underlying circuits, cells, and molecules are just beginning to be delineated. Implicated is a subtype of serotonergic neuron denoted

Indexed as

Dorsal Raphe NucleusSerotonergic NeuronsAcousticsAnimalsFemaleMaleMiceReflex, StartleSerotoninSerotoninacoustic startledominancedopamine receptorrapheserotoninsex differences

Identifiers

PMID33214315
PMCPMC7768286
OpenAlexW3106335269

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.