ArticleScience (New York, N.Y.)2020
Tailored quinones support high-turnover Pd catalysts for oxidative C-H arylation with O
Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Rhodium-Catalyzed Arene Alkenylation Using Benzoquinone Derivatives as Oxidants.Organometallics · 2026Article
- Diversity-Oriented C-H Activation Reactions of the Naphthalene Scaffold.Journal of the American Chemical Society · 2025Article
- Synergistic solvent-catalyst paradigm for sustainable aerobic allylic C-H functionalization.National science review · 2025Article
- Divergent Kinetic/Thermodynamic Selectivity in Palladium(II)-Mediated C-H Activation to Form 5- and 6-Membered Palladacycles.Journal of the American Chemical Society · 2025Article
- Ruthenium Catalyzed Ortho-Arylation Reaction of Benzoic Acids with Arylthianthrenium Salts.Angewandte Chemie (International ed. in English) · 2025Article
- Iridium porphyrin-catalysed asymmetric carbene insertion into primary N-adjacent C-H bonds with TON over 1000000.Nature communications · 2025Article
- Overcoming Pd Catalyst Deactivation in the C-H Coupling of Tryptophan Residues in Water Using Air as the Oxidant.ACS catalysis · 2024Article
- Unified Synthesis of 2-Isocyanoallopupukeanane and 9-Isocyanopupukeanane through a "Contra-biosynthetic" Rearrangement.Angewandte Chemie (International ed. in English) · 2024Article
- Palladium-Catalyzed Electrooxidative Double C-H Arylation.Journal of the American Chemical Society · 2024Article
- Investigation of Weak Noncovalent Interactions Directed by the Amino Substituent of Pyrido- and Pyrimido-[1,2-ACS omega · 2023Article
- Mechanism and Selectivity of Copper-Catalyzed Bromination of Distal C(spOrganometallics · 2023Article
- C-H Glycosylation of Native Carboxylic Acids: Discovery of Antidiabetic SGLT-2 Inhibitors.ACS central science · 2023Article
- Article
- In-situ Kinetic Studies of Rh(II)-Catalyzed C-H Functionalization to Achieve High Catalyst Turnover Numbers.ACS catalysis · 2022Article
- Visible light-driven efficient palladium catalyst turnover in oxidative transformations within confined frameworks.Nature communications · 2022Article
- Computational Study of Key Mechanistic Details for a Proposed Copper (I)-Mediated Deconstructive Fluorination ofTopics in catalysis · 2022Article
- Efficient Aerobic Oxidation of Organic Molecules by Multistep Electron Transfer.Angewandte Chemie (International ed. in English) · 2021Review
- A tautomeric ligand enables directed C‒H hydroxylation with molecular oxygen.Science (New York, N.Y.) · 2021Article
- Benzoquinone Cocatalyst Contributions to DAF/Pd(OAc)ACS catalysis · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Palladium(II)-catalyzed carbon-hydrogen (C-H) oxidation reactions could streamline the synthesis of pharmaceuticals, agrochemicals, and other complex organic molecules. Existing methods, however, commonly exhibit poor catalyst performance with high palladium (Pd) loading (e.g., 10 mole %) and a need for (super)stoichiometric quantities of undesirable oxidants, such as benzoquinone and silver(I) salts. The present study probes the mechanism of a representative Pd-catalyzed oxidative C-H arylation reaction and elucidates mechanistic features that undermine catalyst performance, including substrate-consuming side reactions and sequestration of the catalyst as an inactive species. Systematic tuning of the quinone cocatalyst overcomes these deleterious features. Use of 2,5-di-
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