Evidence map›Paper›PMID 33214251›Full record

ArticleScience (New York, N.Y.)2020

Comment on "Ancient origins of allosteric activation in a Ser-Thr kinase".

Yeonwoo Park, Jaeda E J Patton, Georg K A Hochberg, Joseph W Thornton

Abstract readComment
In one paragraph

Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Origins of allostery in vertebrate hemoglobin evolution.bioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. Evidence for an early green/red photocycle that precedes the diversification of GAF domain photoreceptor cyanobacteriochromes.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  5. Review
  6. Setting the stage for evolution of a new enzyme.Current opinion in structural biology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Yeonwoo Park *Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-3665-8002
Jaeda E J Patton *Committee on Genetics, Genomics and Systems Biology, University of Chicago, Chicago, IL, USA.ORCID 0000-0002-1093-9607
Georg K A HochbergMax Planck Institute for Terrestrial Microbiology, Marburg, Germany.ORCID 0000-0002-7155-0451
Joseph W ThorntonDepartment of Human Genetics, University of Chicago, Chicago, IL, USA. joet1@uchicago.edu.ORCID 0000-0001-9589-6994

Funding

Deep characterization of the sequence space and evolutionary trajectories of reconstructed ancestral proteins - Resubmission 01R01GM121931 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2017 to 2020
$1.3M
Evolution of molecular complexes: genetic, structural, and functional mechanisms for the evolution of oligomers and allosteryR01GM131128 · NIGMS · UNIVERSITY OF CHICAGO · PI THORNTON, JOSEPH W · 2019 to 2021
$904k
NIGMS NIH HHS R01 GM121931NIGMS NIH HHS R01 GM131128
6 · The paper itself

Abstract

Hadzipasic

Indexed as

Aurora KinasesAllosteric RegulationAmino Acid SequencePhylogenyAurora Kinases

Identifiers

PMID33214251
PMCPMC8162921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.