ReviewLupus science & medicine2020
Towards a practical management of fatigue in systemic lupus erythematosus.
Review in Lupus science & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07398885 (Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Assessing the Impact of Herbal Supplement on Fatigue and Disease Activity in SLE: Results From an 8-Week Randomized Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- The Systemic Lupus Erythematosus Interventional Trials in Mainland China: A Continuous Challenge.Frontiers in immunology · 2022Pooled it
- Effect Of treatment on serum C3, C4, IL-10, IL1-β, IL-6, TNF-α in patients with systemic lupus erythematosus.Journal of medical biochemistry · 2026Article
- Pathophysiological mechanisms of fatigue and multidisciplinary management strategies (Review).Experimental and therapeutic medicine · 2026Review
- Cross-sectional survey to determine fatigue in patients with systemic lupus erythematosus.Frontiers in psychology · 2024Article
- COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus.Journal of clinical medicine · 2023Article
- Review
- Systemic Lupus Erythematous and Obstructive Sleep Apnea: A Possible Association.Life (Basel, Switzerland) · 2023Article
- Effects of illness perception on negative emotions and fatigue in chronic rheumatic diseases: Rumination as a possible mediator.World journal of clinical cases · 2022Article
- Article
- The FATIGUE-PRO: a new patient-reported outcome instrument to quantify fatigue in patients affected by systemic lupus erythematosus.Rheumatology (Oxford, England) · 2022Article
- Fatigue in Systemic Lupus Erythematosus: An Update on Its Impact, Determinants and Therapeutic Management.Journal of clinical medicine · 2021Review
- Fatigue in Systemic Lupus Erythematosus and Rheumatoid Arthritis: A Comparison of Mechanisms, Measures and Management.Journal of clinical medicine · 2021Review
- Article
- The Main Challenges in Systemic Lupus Erythematosus: Where Do We Stand?Journal of clinical medicine · 2021Review
- The Lived Experiences of Iranian Patients with Rheumatoid Arthritis: A Qualitative Research.Iranian journal of nursing and midwifery researchArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant fatigue is reported by two-thirds of patients with SLE and severe fatigue by one-third. The assessment and treatment of fatigue remains a major challenge in SLE, especially in patients with no disease activity. Here, we suggest a practical algorithm for the management of fatigue in SLE. First, common but non-SLE-related causes of fatigue should be ruled out based on medical history, clinical and laboratory examinations. Then, presence of SLE-related disease activity or organ damage should be assessed. In patients with active disease, remission is the most appropriate therapeutic target while symptomatic support is needed in case of damage. Both anxiety and depression are major independent predictors of fatigue in SLE and require dedicated assessment and care with psychological counselling and pharmacological intervention if needed. This practical algorithm will help in improving the management of one the most common and complex patient complaints in SLE.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.