Evidence map›Paper›PMID 33214146›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

TAO-kinase 3 governs the terminal differentiation of NOTCH2-dependent splenic conventional dendritic cells.

Matthias Vanderkerken, Bastiaan Maes, Lana Vandersarren, Wendy Toussaint, Kim Deswarte, Manon Vanheerswynghels, Philippe Pouliot, Liesbet Martens, Sofie Van Gassen, Connie M Arthur and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. In Vitro Generation of Murine CD8αMethods in molecular biology (Clifton, N.J.) · 2023
    Article
  10. Nuclear speckle integrity and function require TAO2 kinase.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Posttranslational modifications by ADAM10 shape myeloid antigen-presenting cell homeostasis in the splenic marginal zone.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 3 countries.

Matthias VanderkerkenLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium; matthias.vanderkerken@ugent.be bart.lambrecht@ugent.vib.be.ORCID 0000-0002-0785-5904
Bastiaan MaesLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.ORCID 0000-0003-1594-8622
Lana VandersarrenLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.ORCID 0000-0002-0312-6560
Wendy ToussaintLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Kim DeswarteLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Manon VanheerswynghelsLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.ORCID 0000-0001-9082-2267
Philippe PouliotLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.ORCID 0000-0002-9608-3642
Liesbet MartensDepartment of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.
Sofie Van GassenDepartment of Biomedical Molecular Biology, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-7119-5330
Connie M ArthurDepartment of Pathology and Laboratory Medicine, Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30322.
Margaret E KirklingDepartment of Pathology, New York University School of Medicine, New York, NY 10016.ORCID 0000-0003-1202-335X
Boris ReizisDepartment of Pathology, New York University School of Medicine, New York, NY 10016.ORCID 0000-0003-1140-7853
Daniel ConradCenter for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298.
Sean StowellDepartment of Pathology and Laboratory Medicine, Center for Transfusion Medicine and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30322.
Hamida HammadLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium.
Bart N LambrechtLaboratory of Immunoregulation and Mucosal Immunology, VIB Center for Inflammation Research, 9000 Ghent, Belgium; matthias.vanderkerken@ugent.be bart.lambrecht@ugent.vib.be.
Ghent University · BEEmory University · USNew York University · USErasmus MC · NLVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-presenting conventional dendritic cells (cDCs) are broadly divided into type 1 and type 2 subsets that further adapt their phenotype and function to perform specialized tasks in the immune system. The precise signals controlling tissue-specific adaptation and differentiation of cDCs are currently poorly understood. We found that mice deficient in the Ste20 kinase Thousand and One Kinase 3 (TAOK3) lacked terminally differentiated ESAM

Indexed as

Cell DifferentiationAnimalsAntigens, CDCD4-Positive T-LymphocytesDendritic CellsGene Expression RegulationIntestine, SmallMice, Inbred C57BLPhenotypeProtein DomainsProtein KinasesReceptor, Notch2Signal TransductionSpleenAntigens, CDNotch2 protein, mouseProtein KinasesReceptor, Notch2dendritic cellNotch signalingthousand and one kinase

Identifiers

PMID33214146
PMCPMC7733863
OpenAlexW3099079516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.