Evidence map›Paper›PMID 33214125›Full record

ArticleRedox biology2020

Evidence of complement dysregulation in outer retina of Stargardt disease donor eyes.

Jane Hu, Gayle J Pauer, Stephanie A Hagstrom, Dean Bok, Meghan J DeBenedictis, Vera L Bonilha, Joe G Hollyfield, Roxana A Radu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 22 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Time Course of Structural, Functional, Complement Changes and Inflammatory Processes in a Sodium Iodate Rat Model of Geographic Atrophy.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  7. Dysregulated DNA Methylation inInternational journal of molecular sciences · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Oxidation of DJ-1 Cysteines in Retinal Pigment Epithelium Function.International journal of molecular sciences · 2022
    Article
  17. Article
  18. Article
  19. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jane HuUCLA Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Gayle J PauerDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Stephanie A HagstromDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.
Dean BokUCLA Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, 90095, USA.
Meghan J DeBenedictisDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Vera L BonilhaDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.
Joe G HollyfieldDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44195, USA.
Roxana A RaduUCLA Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, CA, 90095, USA. Electronic address: radu@jsei.ucla.edu.
Cleveland Clinic · USUniversity of California, Los Angeles · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BELA ANAND-APTE · 2016 to 2026
$7.7M
RPE, aging and age-related macular degeneration: the role of oxidative stressR01EY027750 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI BONILHA, VERA L · 2017 to 2021
$2.0M
The Role of Complement in Recessive Stargardt DiseaseR01EY025002 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RADU, ROXANA A · 2015 to 2019
$1.9M
NEI NIH HHS P30 EY000331NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY025002NEI NIH HHS R01 EY027750
6 · The paper itself

Abstract

Stargardt macular degeneration (STGD) is a central blinding disease caused by loss of or dysfunctional ABCA4 transporter in both photoreceptors and retinal pigment epithelial (RPE) cells. Toxic bisretinoid-lipofuscin buildup in the RPE cells is a pathological hallmark of STGD patients and its mouse model, the Abca4

Indexed as

Macular DegenerationRetinal Pigment EpitheliumAnimalsATP-Binding Cassette TransportersHumansMiceRetinaStargardt DiseaseABCA4 protein, humanAbca4 protein, mouseATP-Binding Cassette TransportersAge-related macular degenerationBisretinoid-lipofuscinComplement systemMembrane attack complexRetinal pigment epitheliumStargardt disease

Identifiers

PMID33214125
PMCPMC7767765
OpenAlexW3103066991

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.