Evidence map›Paper›PMID 33213866›Full record

Observational studyBrazilian journal of anesthesiology (Elsevier)

[S100B level and cognitive dysfunction after robotic-assisted laparoscopic radical prostatectomy procedures: a prospective observational study].

Nilgun Kavrut Ozturk, Ali Sait Kavakli, Ulku Arslan, Guzin Aykal, Murat Savas

Registry-linked trialOpen access · diamondAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03018522 (S100B Protein as Predictor of Cognitive Dysfunction After Robot-assisted Radical Prostatectomy), which is not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03018522 completednot on this map

S100B Protein as Predictor of Cognitive Dysfunction After Robot-assisted Radical Prostatectomy: A Prospective Observational Study

TypeobservationalSponsorAntalya Training and Research HospitalRan2017 to 2018Enrolled89ConditionsPostoperative Cognitive DysfunctionArmsPostoperative cognitive dysfunction
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nilgun Kavrut OzturkUniversity of Health Sciences Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation, Antalya, Turquia. Electronic address: kavrut@yahoo.com.
Ali Sait KavakliUniversity of Health Sciences Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation, Antalya, Turquia.
Ulku ArslanUniversity of Health Sciences Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation, Antalya, Turquia.
Guzin AykalUniversity of Health Sciences Antalya Training and Research Hospital, Central Laboratories, Antalya, Turquia.
Murat SavasUniversity of Health Sciences Antalya Training and Research Hospital, Department of Urology, Antalya, Turquia.
Antalya Eğitim ve Araştırma Hastanesi · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe present study investigated the association between Postoperative Cognitive Dysfunction (POCD) and increased serum S100B level after Robotic-Assisted Laparoscopic Radical Prostatectomy (RALRP).

methodsThe study included 82 consecutive patients who underwent RALRP. Serum S100B levels were determined preoperatively, after anesthesia induction, and at 30 minutes and 24 hours postoperatively. Cognitive function was assessed using neuropsychological testing preoperatively and at 7 days and 3 months postoperatively.

resultsTwenty-four patients (29%) exhibited POCD 7 days after surgery, and 9 (11%) at 3 months after surgery. Serum S100B levels were significantly increased at postoperative 30minutes and 24 hours in patients displaying POCD at postoperative 7 days (p = 0.0001 for both) and 3 months (p = 0.001 for both) compared to patients without POCD. Duration of anesthesia was also significantly longer in patients with POCD at 7 days and 3 months after surgery compared with patients without POCD (p = 0.012, p = 0.001, respectively), as was duration of Trendelenburg (p = 0.025, p = 0.002, respectively). Composite Z score in tests performed on day 7 were significantly correlated with duration of Trendelenburg and duration of anesthesia (p = 0.0001 for both).

conclusionsS100B increases after RALRP and this increase is associated with POCD development. Duration of Trendelenburg position and anesthesia contribute to the development of POCD. TRIAL REGISTRY NUMBER: Clinicaltrials.gov (N° NCT03018522).

Indexed as

AgedAnesthesia, GeneralArea Under CurveBiomarkersCase-Control StudiesCognitive DysfunctionHead-Down TiltHumansMaleMiddle AgedNeuropsychological TestsOperative TimePostoperative ComplicationsProspective StudiesProstatectomyRobotic Surgical ProceduresBiomarkersS100B protein, humanS100 Calcium Binding Protein beta SubunitDisfunção cognitiva pós‐operatóriaPostoperative cognitive dysfunctionProstatectomia radical laparoscópica assistida por robôRobotic assisted laparoscopic radical prostatectomyS100BS100B protein

Identifiers

PMID33213866
PMCPMC9373553
OpenAlexW3091886632

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.