Evidence map›Paper›PMID 33213556›Full record

ReviewCNS spectrums2022

Differentiating tardive dyskinesia: a video-based review of antipsychotic-induced movement disorders in clinical practice.

Robert A Hauser, Jonathan M Meyer, Stewart A Factor, Cynthia L Comella, Caroline M Tanner, Rose Mary Xavier, Stanley N Caroff, Leslie Lundt

Abstract readReview
In one paragraph

Review in CNS spectrums, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  15. Article
  16. Telehealth for Assessing and Managing Tardive Dyskinesia: Expert Insights from a Cross-Disciplinary Virtual Treatment Panel.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2023
    Article
  17. Article
  18. Review
  19. Risk of Drug-induced Movement Disorders with Newer Antipsychotic Agents.Tremor and other hyperkinetic movements (New York, N.Y.) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert A HauserDepartment of Neurology, University of South Florida Parkinson's Disease and Movement Disorders Center, Tampa, Florida, USA.ORCID 0000-0002-6369-1203
Jonathan M MeyerDepartment of Psychiatry, University of California, San Diego, La Jolla, California, USA.ORCID 0000-0001-7294-4834
Stewart A FactorDepartment of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA.
Cynthia L ComellaDepartment of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA.
Caroline M TannerSan Francisco Veterans Affairs Health Care System, Department of Neurology, University of California San Francisco, San Francisco, California, USA.
Rose Mary XavierSchool of Nursing, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stanley N CaroffPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Leslie LundtMedical Affairs, Neurocrine Biosciences, Inc., San Diego, California, USA.

Funding

Dystonia Coalition- Pilot ProjectU54NS116025 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2019 to 2023
$7.1M
Dystonia CoalitionU54NS065701 · NINDS · EMORY UNIVERSITY · PI JINNAH, HYDER A · 2009 to 2014
$7.0M
Exploratory study of different doses of endurance exercise in people with ParkinsR01NS074343 · NINDS · UNIVERSITY OF COLORADO DENVER · PI CORCOS, DANIEL M., SCHENKMAN, MARGARET L · 2011 to 2014
$3.0M
Emory Clinical Research Site for NEXTU10NS077366 · NINDS · EMORY UNIVERSITY · PI FACTOR, STEWART A · 2011 to 2017
$1.8M
NINDS NIH HHS R01 NS074343NINDS NIH HHS U10 NS077366NINDS NIH HHS U54 NS065701NINDS NIH HHS U54 NS116025
6 · The paper itself

Abstract

Accurate diagnosis and appropriate treatment of tardive dyskinesia (TD) are imperative, as its symptoms can be highly disruptive to both patients and their caregivers. Misdiagnosis can lead to incorrect interventions with suboptimal or even deleterious results. To aid in the identification and differentiation of TD in the psychiatric practice setting, we review its clinical features and movement phenomenology, as well as those of other antipsychotic-induced movement disorders, with accompanying links to illustrative videos. Exposure to dopamine receptor blocking agents (DRBAs) such as antipsychotics or antiemetics is associated with a spectrum of movement disorders including TD. The differential diagnosis of TD is based on history of DRBA exposure, recent discontinuation or dose reduction of a DRBA, and movement phenomenology. Common diagnostic challenges are the abnormal behaviors and dyskinesias associated with advanced age or chronic mental illness, and other movement disorders associated with DRBA therapy, such as akathisia, parkinsonian tremor, and tremor related to use of mood stabilizing agents (eg, lithium, divalproex). Duration of exposure may help rule out acute drug-induced syndromes such as acute dystonia or acute/subacute akathisia. Another important consideration is the potential for TD to present together with other drug-induced movement disorders (eg, parkinsonism, parkinsonian tremor, and postural tremor from mood stabilizers) in the same patient, which can complicate both diagnosis and management. After documentation of the phenomenology, severity, and distribution of TD movements, treatment options should be reviewed with the patient and caregivers.

Indexed as

Antipsychotic AgentsMovement DisordersTardive DyskinesiaHumansPsychomotor AgitationTremorAntipsychotic Agentsdrug-induced movement disorderstardive dyskinesiatreatmentvideosVMAT2 inhibitors

Identifiers

PMID33213556
PMCPMC9249122

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.