ArticleMicrobiome2020
Antimicrobial use and production system shape the fecal, environmental, and slurry resistomes of pig farms.
Article in Microbiome, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 80 citations in OpenAlex.
- Exploratory analysis of livestock waste treatment impacts on microbial diversity and antimicrobial resistance gene abundance.Microbiology spectrum · 2026Article
- Metagenomic analysis reveals resistome characteristics and high-risk resistance genes in the pig nasal cavities, feces, and farm dust.Animal microbiome · 2026Article
- Dietary iron and metal-based growth promoters differentially modulate the gut resistome and Escherichia coli virulome in weaned pigs.Journal of animal science and biotechnology · 2026Article
- Microbiome and resistome successions in pig carcasses and fresh pork meat throughout slaughtering, processing and shelf-life.Microbiome · 2026Article
- The resistome bridge between livestock and workers: novel frameworks for early detection and monitoring of antimicrobial resistance.Frontiers in public health · 2026Review
- Impact of Organic and Conventional Husbandry Systems on the Gut Microbiome and Resistome in Pigs.Microorganisms · 2025Article
- High-fat and low-fiber diet elevates the gut resistome: a comparative metagenomic study.NPJ biofilms and microbiomes · 2025Article
- Genomic epidemiology of antimicrobial resistance determinants in Chinese swine farmFrontiers in microbiology · 2025Article
- A qualitative content analysis exploring the portrayal of antibiotic use and antibiotic resistance in UK smallholding print media.Frontiers in veterinary science · 2025Article
- Distribution of antibiotic resistance genes and their pathogen hosts in duck farm environments in south-east coastal China.Applied microbiology and biotechnology · 2024Review
- Article
- Genomic characterization of a clonal emergentApplied and environmental microbiology · 2024Article
- The resistome of the food chain: A One Health perspective.Microbial biotechnology · 2024Review
- The gut microbiota in persistent post-operative pain following breast cancer surgery.Scientific reports · 2024Observational
- Resistome in the indoor dust samples from workplaces and households: a pilot study.Frontiers in cellular and infection microbiology · 2024Article
- Swine farm environmental microbiome: exploring microbial ecology and functionality across farms with high and low sanitary status.Frontiers in veterinary science · 2024Article
- Metagenomic insights into microbial community, functional annotation, and antibiotic resistance genes in Himalayan Brahmaputra River sediment, India.Frontiers in microbiology · 2024Article
- Metagenomic comparison of the faecal and environmental resistome on Irish commercial pig farms with and without zinc oxide and antimicrobial usage.Animal microbiome · 2023Article
- Antibiotic resistance gene-free probiont administration to tilapia for growth performance andVeterinary world · 2023Article
- Microbiome Interconnectedness throughout Environments with Major Consequences for Healthy People and a Healthy Planet.Microbiology and molecular biology reviews : MMBR · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe global threat of antimicrobial resistance (AMR) is a One Health problem impacted by antimicrobial use (AMU) for human and livestock applications. Extensive Iberian swine production is based on a more sustainable and eco-friendly management system, providing an excellent opportunity to evaluate how sustained differences in AMU impact the resistome, not only in the animals but also on the farm environment. Here, we evaluate the resistome footprint of an extensive pig farming system, maintained for decades, as compared to that of industrialized intensive pig farming by analyzing 105 fecal, environmental and slurry metagenomes from 38 farms.
resultsOur results evidence a significantly higher abundance of antimicrobial resistance genes (ARGs) on intensive farms and a link between AMU and AMR to certain antimicrobial classes. We observed differences in the resistome across sample types, with a higher richness and dispersion of ARGs within environmental samples than on those from feces or slurry. Indeed, a deeper analysis revealed that differences among the three sample types were defined by taxa-ARGs associations. Interestingly, mobilome analyses revealed that the observed AMR differences between intensive and extensive farms could be linked to differences in the abundance of mobile genetic elements (MGEs). Thus, while there were no differences in the abundance of chromosomal-associated ARGs between intensive and extensive herds, a significantly higher abundance of integrons in the environment and plasmids, regardless of the sample type, was detected on intensive farms.
conclusionsOverall, this study shows how AMU, production system, and sample type influence, mainly through MGEs, the profile and dispersion of ARGs in pig production. Video Abstract.
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