ArticleBMC infectious diseases2020
Routine blood parameters are helpful for early identification of influenza infection in children.
Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 37 citations in OpenAlex.
- Complete Blood Count-Derived Inflammatory Markers in Pediatric Lower Respiratory Tract Infection: A Narrative Review.Pathogens (Basel, Switzerland) · 2026Review
- Validity of complete blood count in detecting influenza among clinically suspected children in Sri Lanka: a retrospective study from low resource setting country.BMC infectious diseases · 2026Article
- Association Between Mean Platelet Volume and Other Inflammatory Markers in Patients with Influenza A (H1N1).The Eurasian journal of medicine · 2025Article
- The Neutrophil/Lymphocyte Ratio Was Identified as a Marker of Severe Influenza During the 2024-2025 Outbreak in France.Infectious disease reports · 2025Article
- Seasonal Distribution of Viral Pneumonia After COVID-19 and the Role of Hematological Markers in Assessing Pneumonia Severity: A Case-Control Study.Tropical medicine and infectious disease · 2025Article
- Evaluation of a Machine Learning Model Based on Laboratory Parameters for the Prediction of Influenza A and B in Chongqing, China: Multicenter Model Development and Validation Study.Journal of medical Internet research · 2025Article
- Clinical and Paraclinical Peculiarities of SARS-CoV-2 and Influenza Infections in Children: A Comparative Study.Life (Basel, Switzerland) · 2025Article
- The value of common blood parameters for the differential diagnosis of respiratory tract infections in children.AMB Express · 2025Article
- The highly accuracy of lymphocyte count in diagnosing influenza A in children during the influenza A season.Frontiers in pediatrics · 2025Article
- A preliminary prediction model of pediatric Mycoplasma pneumoniae pneumonia based on routine blood parameters by using machine learning method.BMC infectious diseases · 2024Article
- Pediatric Respiratory Infections After the COVID-19 Pandemic: A Single-Center Experience.Cureus · 2024Article
- Diagnostic value of routine blood tests in differentiating between SARS-CoV-2, influenza A, and RSV infections in hospitalized children: a retrospective study.BMC pediatrics · 2024Article
- The blood routine test holds screening values for influenza A in 2023: a retrospective study.Translational pediatrics · 2024Article
- A diagnostic model based on routine blood examination for serious bacterial infections in neonates-a cross-sectional study.Epidemiology and infection · 2023Article
- Platelet Abnormalities in Children with Laboratory-Confirmed Influenza.Diagnostics (Basel, Switzerland) · 2023Article
- Risk factors for hospitalization and pneumonia development of pediatric patients with seasonal influenza during February-April 2023.Frontiers in public health · 2023Article
- Review on the Biogenesis of Platelets in Lungs and Its Alterations in SARS-CoV-2 Infection Patients.Journal of the renin-angiotensin-aldosterone system : JRAAS · 2023Review
- Immunohistochemistry Staining-Proven Cytomegalovirus Colitis in Living Donor Liver Transplantation.Viruses · 2022Article
- Platelet-Released Factors: Their Role in Viral Disease and Applications for Extracellular Vesicle (EV) Therapy.International journal of molecular sciences · 2022Review
- Monocyte-to-Lymphocyte Ratio in the Diagnosis of Lymphoma in Adult Patients.International journal of general medicine · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRoutine blood parameters, such as the lymphocyte (LYM) count, platelet (PLT) count, lymphocyte-to-monocyte ratio (LMR), neutrophil-to-lymphocyte ratio (NLR), lymphocytes multiplied by platelets (LYM*PLT) and mean platelet volume-to-platelet ratio (MPV/PLT), are widely used to predict the prognosis of infectious diseases. We aimed to explore the value of these parameters in the early identification of influenza virus infection in children.
methodsWe conducted a single-center, retrospective, observational study of fever with influenza-like symptoms in pediatric outpatients from different age groups and evaluated the predictive value of various routine blood parameters measured within 48 h of the onset of fever for influenza virus infection.
resultsThe LYM count, PLT count, LMR and LYM*PLT were lower, and the NLR and MPV/PLT were higher in children with an influenza infection (PCR-confirmed and symptomatic). The LYM count, LMR and LYM*PLT in the influenza infection group were lower in the 1- to 6-year-old subgroup, and the LMR and LYM*PLT in the influenza infection group were lower in the > 6-year-old subgroup. In the 1- to 6-year-old subgroup, the cutoff value of the LMR for predicting influenza A virus infection was 3.75, the sensitivity was 81.87%, the specificity was 84.31%, and the area under the curve (AUC) was 0.886; the cutoff value of the LMR for predicting influenza B virus infection was 3.71, the sensitivity was 73.58%, the specificity was 84.31%, and the AUC was 0.843. In the > 6-year-old subgroup, the cutoff value of the LMR for predicting influenza A virus infection was 3.05, the sensitivity was 89.27%, the specificity was 89.61%, and the AUC was 0.949; the cutoff value of the LMR for predicting influenza B virus infection was 2.88, the sensitivity was 83.19%, the specificity was 92.21%, and the AUC was 0.924.
conclusionsRoutine blood tests are simple, inexpensive and easy to perform, and they are useful for the early identification of influenza virus infection in children. The LMR had the strongest predictive value for influenza virus infection in children older than 1 year, particularly in children older than 6 years with influenza A virus infection.
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