Evidence map›Paper›PMID 33213373›Full record

ArticleBMC immunology2020

Sex and FOXP3 gene rs2232365 polymorphism may be associated with the clinical and pathological aspects of chronic viral diseases.

Leonn Mendes Soares Pereira, Max Willy da Silva Madureira, Renata Bezerra Hermes de Castro, Isabella Nogueira Abreu, Simone Regina Souza da Silva Conde, Sâmia Demachki, Maisa Silva de Sousa, Maria Alice Freitas Queiroz, Andrea Nazaré M Rangel da Silva, Sandra Souza Lima and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Leonn Mendes Soares PereiraVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Max Willy da Silva MadureiraVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Renata Bezerra Hermes de CastroHematology and Hemotherapy Center Foundation of the State of Pará (Fundação Centro de Hematologia e Hemoterapia do Estado do Pará), Belém, Brazil.
Isabella Nogueira AbreuVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Simone Regina Souza da Silva CondeMedical School, Biological Sciences Institute, UFPA, Belém, Brazil.
Sâmia DemachkiMedical School, Biological Sciences Institute, UFPA, Belém, Brazil.
Maisa Silva de SousaTropical Medicine Center, UFPA, Belém, Brazil.
Maria Alice Freitas QueirozVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Andrea Nazaré M Rangel da SilvaVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Sandra Souza LimaVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Marluísa de Oliveira Guimarães IshakVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Ricardo IshakVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil.
Antonio Carlos Rosário VallinotoVirology Laboratory, Biological Sciences Institute, Federal University of Pará (Universidade Federal do Pará - UFPA), Belém, Brazil. vallinoto@ufpa.br.ORCID 0000-0003-1135-6507
Universidade Federal do Pará · BRFundação Hemopa · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 301869/2017-0Conselho Nacional de Desenvolvimento Científico e Tecnológico 480128/2013-8Fundação Amazônia Paraense de Amparo à Pesquisa ICAAF-092/2010
6 · The paper itself

Abstract

backgroundThe forkhead box protein 3 (FOXP3) transcription factor is one of the main markers of immunological suppression in different pathological profiles, and the presence of polymorphic variants may alter the gene expression of this factor. Despite descriptions of an association between the presence of the rs2232365 polymorphism and chronic diseases, the role of the sex variant in this context has not yet been elucidated, as the FOXP3 gene is located on the human sex chromosome X.

resultsTo contribute to this topic, 323 women and 373 men were enrolled in the study, of which 101 were diagnosed with chronic viral liver diseases (39 women and 62 men), 67 with HTLV-1 infection (44 women and 23 men), 230 with coronary artery disease (91 women and 139 men) and 298 healthy and uninfected blood donors (149 women and men). They were genotyped for the rs2232365 polymorphism. The rs2232365 polymorphism was associated with clinical and pathological aspects and biomarkers of viral infections only in men, with functional differences between different infections.

conclusionsA relationship is suggested between sex and FOXP3 rs2232365 polymorphism, resulting in different biological repercussions.

Indexed as

GenotypeSex FactorsAdultCase-Control StudiesChronic DiseaseCoronary Artery DiseaseFemaleForkhead Transcription FactorsGenetic Predisposition to DiseaseHTLV-I InfectionsHumansHuman T-lymphotropic virus 1MalePolymorphism, Single NucleotideForkhead Transcription FactorsFOXP3 protein, humanChronic viral diseasesFOXP3PolymorphismSex

Identifiers

PMID33213373
PMCPMC7678194
OpenAlexW3098264941

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.