ReviewTissue engineering. Part B, Reviews2022
Biomaterials-Driven Sterile Inflammation.
Review in Tissue engineering. Part B, Reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- DAMP signaling networks: from receptors to diverse pathophysiological functions.Journal of advanced research · 2026Review
- Hip Labral Reconstruction With a Synthetic Graft: Development and Preclinical Validation.Orthopaedic surgery · 2026Article
- Application of PLCL as a biodegradable polymer in biomedical engineering.Journal of materials science. Materials in medicine · 2026Review
- Prospects and challenges of traditional Chinese medicine supramolecular nano-drug delivery systems in the treatment of cerebral ischemia.Frontiers in pharmacology · 2026Review
- Dual stimulus-responsive dECM cryogel sequentially regulate bone microenvironment for one-step surgical therapy of chronic osteomyelitis.Materials today. Bio · 2025Article
- Engineered Healing: Synergistic Use of Schwann Cells and Biomaterials for Spinal Cord Regeneration.International journal of molecular sciences · 2025Review
- Bilayer book- like decellularized extracellular matrix scaffold with bioactive coatings for rotator cuff repair.Materials today. Bio · 2025Article
- Xanthohumol bulk-modified polyurethane for tracheal repair: A 'killing two birds with one stone' strategy for tailorable mechanics and durable anti-inflammatory efficacy.Materials today. Bio · 2025Article
- Targeting RAGE-signaling pathways in the repair of rotator-cuff injury.Molecular and cellular biochemistry · 2025Review
- Keratin Additive for Cellular Adhesion in Transcutaneous Prosthetics.Journal of tissue engineering and regenerative medicine · 2025Article
- Therapeutic Insulin Analogue Concentrations at Infusion Sites Enhanced the Pro-Inflammatory Response and Apoptosis in an In Vitro Macrophage-Material Interaction Model.ACS pharmacology & translational science · 2024Article
- Open-Spaced Ridged Hydrogel Scaffolds Containing TiOInternational journal of molecular sciences · 2023Article
- Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds.Journal of functional biomaterials · 2023Article
- Improving hard metal implant and soft tissue integration by modulating the "inflammatory-fibrous complex" response.Bioactive materials · 2023Article
- NLRP3 inflammasome activation in response to metals.Frontiers in immunology · 2023Review
- Mitochondrial transplantation as an immunomodulatory strategy: Modulating polymorphonuclear leukocytes for functional tissue regeneration.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Performance of the biomaterials used for regenerative medicine largely depends on biocompatibility; however, the biological mechanisms underlying biocompatibility of a biomaterial within the host system is poorly understood. In addition to the classical immune response against non-self-entities, the sterile inflammatory response could limit the compatibility of biological scaffolds. Whereas the immediate to short-term host response to a biomaterial implant have been characterized, the long-term progression of host-biomaterial relationship has not been described. This article explores the novel concept of biomaterials-driven sterile inflammation (BSI) in long-term biodegradable implants and throws light for possible explanation for the onset of BSI and the associated damage-associated molecular patterns. The understanding of BSI would advance the current strategies to improve biomaterial-host tissue integration and open novel translational avenues in biomaterials-based tissue regeneration. Impact statement Understanding the novel concept of biomaterials-driven sterile inflammation and associated damage-associated molecular patterns in long-term biodegradable implants would determine their success and improves the tissue engineering and regenerative strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.