Evidence map›Paper›PMID 33213108›Full record

ArticleJournal of clinical medicine2020

Driver Mutations and Single Copy Number Abnormalities Identify Binet Stage A Patients with Chronic Lymphocytic Leukemia with Aggressive Progression.

Ana P Gonzalez-Rodriguez, Angel R Payer, Juan J Menendez-Suarez, Christian Sordo-Bahamonde, Seila Lorenzo-Herrero, Joud Zanabili, Ariana Fonseca, Ana Julia Gonzalez-Huerta, Pilar Palomo, Segundo Gonzalez

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ana P Gonzalez-RodriguezDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.ORCID 0000-0002-0565-9133
Angel R PayerDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Juan J Menendez-SuarezDepartamento de Biología Funcional, Inmunología, Universidad de Oviedo, 33006 Oviedo, Spain.
Christian Sordo-BahamondeInstituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain.ORCID 0000-0002-9755-6149
Seila Lorenzo-HerreroInstituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain.
Joud ZanabiliDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Ariana FonsecaDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Ana Julia Gonzalez-HuertaDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Pilar PalomoDepartment of Hematology, Hospital Universitario Central de Asturias (HUCA), 33011 Oviedo, Spain.
Segundo GonzalezInstituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Spain.ORCID 0000-0003-4631-9255
Hospital Universitario Central de Asturias · ESUniversidad de Oviedo · ES

Funding

Instituto de Salud Carlos III PI19/01353
6 · The paper itself

Abstract

The correlation between progression and the genetic characteristics of Binet stage A patients with chronic lymphocytic leukemia (CLL) detected by whole exome sequencing (WES) was analyzed in 55 patients. The median follow-up for the patients was 102 months. During the follow-up, 24 patients (43%) progressed. Univariate Cox analysis showed that the presence of driver mutations, the accumulation of two or more mutations, the presence of adverse mutations, immunoglobulin heavy chain genes (

Indexed as

Binetchronic lymphocytic leukemiageneticsmutationnext-generation sequencingsingle copy number abnormalitywhole exome sequencing

Identifiers

PMID33213108
PMCPMC7698623
OpenAlexW3102450721

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.