Evidence map›Paper›PMID 33213096›Full record

ArticleGenes2020

Genomic and Transcriptomic Analysis for Identification of Genes and Interlinked Pathways Mediating Artemisinin Resistance in

Sushmita Ghosh, Aditya Verma, Vinay Kumar, Dibyabhaba Pradhan, Angamuthu Selvapandiyan, Poonam Salotra, Ruchi Singh

Open access · goldAbstract read
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Advances in UnderstandingFrontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Sushmita GhoshICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
Aditya VermaICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
Vinay KumarICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.ORCID 0000-0002-8075-1431
Dibyabhaba PradhanICMR-AIIMS Computational Genomics Centre, Indian Council of Medical Research, New Delhi 110029, India.ORCID 0000-0002-2459-5032
Angamuthu SelvapandiyanJH-Institute of Molecular Medicine, Jamia Hamdard, New Delhi 110062, India.
Poonam SalotraICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.
Ruchi SinghICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi 110029, India.ORCID 0000-0001-8094-4703
Safdarjang Hospital · INIndian Council of Medical Research · INJamia Hamdard · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current therapy for visceral leishmaniasis (VL), compromised by drug resistance, toxicity, and high cost, demands for more effective, safer, and low-cost drugs. Artemisinin has been found to be an effectual drug alternative in experimental models of leishmaniasis. Comparative genome and transcriptome analysis of in vitro-adapted artesunate-resistant (K133AS-R) and -sensitive wild-type (K133WT)

Indexed as

AnimalsAntiprotozoal AgentsAquaglyceroporinsArtemisininsArtesunateChromosomesDrug ResistanceGene ExpressionGene FrequencyGenome, ProtozoanHSP70 Heat-Shock ProteinsHumansLeishmania donovaniLeishmaniasis, VisceralMiceProtozoan ProteinsAntiprotozoal AgentsAquaglyceroporinsArtemisininsArtesunateHSP70 Heat-Shock ProteinsProtozoan Proteinsartemisinin drug resistanceLeishmania donovanitranscriptomewhole-genome sequencing (WGS)

Identifiers

PMID33213096
PMCPMC7698566
OpenAlexW3103656071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.