Evidence map›Paper›PMID 33213084›Full record

ArticleMarine drugs2020

Functional Characterization of a New GH107 Endo-α-(1,4)-Fucoidanase from the Marine Bacterium

Marlene Vuillemin, Artem S Silchenko, Hang Thi Thuy Cao, Maxim S Kokoulin, Vo Thi Dieu Trang, Jesper Holck, Svetlana P Ermakova, Anne S Meyer, Maria Dalgaard Mikkelsen

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 36 citations in OpenAlex.

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  11. The Endo-α(1,4) Specific Fucoidanase Fhf2 FromFrontiers in plant science · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Marlene VuilleminProtein Chemistry and Enzyme Technology Section, DTU Bioengineering, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
Artem S SilchenkoG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 159, Prospect 100-let Vladivostoku, 690022 Vladivostok, Russia.
Hang Thi Thuy CaoNhaTrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 02 Hung Vuong Street, Nhatrang 650000, Vietnam.ORCID 0000-0003-3945-6657
Maxim S KokoulinG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 159, Prospect 100-let Vladivostoku, 690022 Vladivostok, Russia.ORCID 0000-0003-2245-6802
Vo Thi Dieu TrangProtein Chemistry and Enzyme Technology Section, DTU Bioengineering, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.ORCID 0000-0003-4969-0594
Jesper HolckProtein Chemistry and Enzyme Technology Section, DTU Bioengineering, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.ORCID 0000-0002-8072-1101
Svetlana P ErmakovaG.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Sciences, 159, Prospect 100-let Vladivostoku, 690022 Vladivostok, Russia.
Anne S MeyerProtein Chemistry and Enzyme Technology Section, DTU Bioengineering, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.ORCID 0000-0001-8910-9931
Maria Dalgaard MikkelsenProtein Chemistry and Enzyme Technology Section, DTU Bioengineering, Department of Biotechnology and Biomedicine, Technical University of Denmark, 2800 Kgs Lyngby, Denmark.
Technical University of Denmark · DKPacific Institute of Bioorganic Chemistry. GB Elyakova Far Eastern Branch of the Russian Academy of Sciences · RUVietnam Academy of Science and Technology · VN

Funding

European Commission H2020 Bio-based Industries Joint Consortium via the Macro Cascade Project 720755Ministry of Science and Technology of Vietnam ĐTĐL.CN-57/19Technical University of Denmark and the FucoSan Program, Health from the Sea Project, supported by EU InterReg-Deutschland-Denmark and the European Fund of Regional Development x
6 · The paper itself

Abstract

Fucoidans from brown macroalgae are sulfated fucose-rich polysaccharides, that have several beneficial biological activities, including anti-inflammatory and anti-tumor effects. Controlled enzymatic depolymerization of the fucoidan backbone can help produce homogeneous, defined fucoidan products for structure-function research and pharmaceutical uses. However, only a few endo-fucoidanases have been described. This article reports the genome-based discovery, recombinant expression in

Indexed as

Amino Acid SequenceBacterial ProteinsCloning, MolecularEnzyme StabilityFlavobacteriaceaeGlycoside HydrolasesHydrogen-Ion ConcentrationHydrolysisPolysaccharidesSodium ChlorideSubstrate SpecificityTemperatureBacterial ProteinsfucoidanGlycoside HydrolasesPolysaccharidesSodium Chloridefucoidanfucoidanasefuco-oligosaccharidesFucus evanescensGH107

Identifiers

PMID33213084
PMCPMC7698502
OpenAlexW3098585525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.