Evidence map›Paper›PMID 33213004›Full record

ArticleNanomaterials (Basel, Switzerland)2020

Novel Benchtop Magnetic Particle Spectrometer for Process Monitoring of Magnetic Nanoparticle Synthesis.

Norbert Löwa, Dirk Gutkelch, Ernst-Albrecht Welge, Roland Welz, Florian Meier, Abdulkader Baki, Regina Bleul, Thorsten Klein, Frank Wiekhorst

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Norbert LöwaPhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany.ORCID 0000-0001-6245-9042
Dirk GutkelchPhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany.
Ernst-Albrecht WelgePhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany.
Roland WelzPostnova Analytics GmbH, Max-Planck-Straße 14, 86899 Landsberg am Lech, Germany.
Florian MeierPostnova Analytics GmbH, Max-Planck-Straße 14, 86899 Landsberg am Lech, Germany.ORCID 0000-0003-1395-4877
Abdulkader BakiFraunhofer Institut für Mikrotechnik und Mikrosysteme IMM, Carl-Zeiss-Straße 18-20, 55129 Mainz, Germany.
Regina BleulFraunhofer Institut für Mikrotechnik und Mikrosysteme IMM, Carl-Zeiss-Straße 18-20, 55129 Mainz, Germany.ORCID 0000-0003-0352-7193
Thorsten KleinPostnova Analytics GmbH, Max-Planck-Straße 14, 86899 Landsberg am Lech, Germany.ORCID 0000-0003-3780-9607
Frank WiekhorstPhysikalisch-Technische Bundesanstalt, Abbestr. 2-12, 10587 Berlin, Germany.ORCID 0000-0003-0608-1473

Funding

Bundesministerium für Wirtschaft und Technologie TransMeT / Magnetische Messtechnik für die Größenfraktionierung magnetischer NanopartikelDeutsche Forschungsgemeinschaft SFB 1340/1 2018, no 372486779, projects A02
6 · The paper itself

Abstract

Magnetic nanoparticles combine unique magnetic properties that can be used in a variety of biomedical applications for therapy and diagnostics. These applications place high demands on the magnetic properties of nanoparticles. Thus, research, development, and quality assurance of magnetic nanoparticles requires powerful analytical methods that are capable of detecting relevant structural and, above all, magnetic parameters. By directly coupling nanoparticle synthesis with magnetic detectors, relevant nanoparticle properties can be obtained and evaluated, and adjustments can be made to the manufacturing process in real time. This work presents a sensitive and fast magnetic detector for online characterization of magnetic nanoparticles during their continuous micromixer synthesis. The detector is based on the measurement of the nonlinear dynamic magnetic response of magnetic nanoparticles exposed to an oscillating excitation at a frequency of 25 kHz, a technique also known as magnetic particle spectroscopy. Our results underline the excellent suitability of the developed magnetic online detection for coupling with magnetic nanoparticle synthesis based on the micromixer approach. The proven practicability and reliability of the detector for process monitoring forms the basis for further application fields, e.g., as a monitoring tool for chromatographic separation processes.

Indexed as

biomedical applicationsmagnetic characterizationmagnetic nanoparticlesmagnetic particle spectroscopyprocess monitoringsynthesis

Identifiers

PMID33213004
PMCPMC7698567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.