Evidence map›Paper›PMID 33212993›Full record

ArticleMicroorganisms2020

Disrupting

Monica C Gestal, Uriel Blas-Machado, Hannah M Johnson, Lily N Rubin, Kalyan K Dewan, Claire Bryant, Michael Tiemeyer, Eric T Harvill

Open access · goldAbstract read
In one paragraph

Article in Microorganisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Living without eosinophils: evidence from mouse and man.The European respiratory journal · 2023
    Review
  9. Generating enhanced mucosal immunity againstFrontiers in immunology · 2023
    Article
  10. Review
  11. Article
  12. Conquering the host:Frontiers in microbiology · 2022
    Review
  13. Eosinophils and Bacteria, the Beginning of a Story.International journal of molecular sciences · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Monica C GestalDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-7417-2460
Uriel Blas-MachadoDepartment of Pathology, Athens Veterinary Diagnostic Laboratory, University of Georgia, Athens, GA 30602, USA.
Hannah M JohnsonDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Lily N RubinDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Kalyan K DewanDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Claire BryantDepartment of Veterinary Medicine, University of Cambridge, Cambridge CB30ES, UK.
Michael TiemeyerComplex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.ORCID 0000-0001-8893-2133
University of Georgia · USUniversity of Cambridge · GB

Funding

Systematic evaluation of B. pertussis ACT’s role as a protective antigenR01AI122753 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI MAYNARD, JENNIFER A · 2016 to 2020
$1.9M
Are acellular vaccines driving the rise of pertactin-deficient Bordetella pertussisR21AI156293 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
Protection against Bordetella pertussis transmission conferred by established and novel vaccinesR21AI159347 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
Bacterial factors and host response in chronic otitis mediaR21DC018496 · NIDCD · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2020 to 2021
$415k
An optimized mouse model of Bordetella pertussis infectionR21AI142678 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2019 to 2020
$414k
A Novel Polysaccharide Structure that Mediates TransmissionR21AI140399 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2018 to 2019
$413k
In vivo vaccine-driven evolution in Bordetella pertussisR21AI116186 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2016
$411k
Vaccine targeting catarrhal stage of pertussis diseaseR56AI149787 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2020 to 2020
$369k
Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases AI122753NIAID NIH HHS R21 AI116186NIAID NIH HHS R21 AI140399NIAID NIH HHS R21 AI142678NIAID NIH HHS R21 AI156293NIAID NIH HHS R21 AI159347NIAID NIH HHS R56 AI149787NIDCD NIH HHS R21 DC018496
6 · The paper itself

Abstract

Recent findings revealed pivotal roles for eosinophils in protection against parasitic and viral infections, as well as modulation of adaptive immune responses in the gastric mucosa. However, the known effects of eosinophils within the respiratory tract remain predominantly pathological, associated with allergy and asthma. Simulating natural respiratory infections in mice, we examined how efficient and well-adapted pathogens can block eosinophil functions that contribute to the immune response.

Indexed as

adaptive immunityBordetella bronchisepticaeosinophilsimmunomodulation

Identifiers

PMID33212993
PMCPMC7698589
OpenAlexW3104009078

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.