Evidence map›Paper›PMID 33212917›Full record

ArticleCancers2020

Real Life Prospective Evaluation of New Drug-Eluting Platform for Chemoembolization of Patients with Hepatocellular Carcinoma: PARIS Registry.

Thierry de Baere, Boris Guiu, Maxime Ronot, Patrick Chevallier, Géraldine Sergent, Illario Tancredi, Lambros Tselikas, Marco Dioguardi Burgio, Lucas Raynaud, Frederic Deschamps and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Thierry de BaereDepartment of Interventional Radiology, Gustave Roussy Cancer Center, 114 rue Edouard Vaillant, 94805 Villejuif, France.ORCID 0000-0002-4556-7663
Boris GuiuImagerie Médicale St Eloi, 34000 Montpellier, France.
Maxime RonotService de Radiologie, Hôpital Beaujon, APHP Nord, Clichy & Université de Paris, 92210 Clichy, France.
Patrick ChevallierService d'Imagerie Médicale Diagnostique et Interventionnelle, Hôpital L'Archet II, 06200 Nice, France.
Géraldine SergentRadiologie & Imagerie Digestive, CHRU Lille, 59037 Lille, France.
Illario TancrediGastroentérologie Médicale, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Lambros TselikasDepartment of Interventional Radiology, Gustave Roussy Cancer Center, 114 rue Edouard Vaillant, 94805 Villejuif, France.
Marco Dioguardi BurgioService de Radiologie, Hôpital Beaujon, APHP Nord, Clichy & Université de Paris, 92210 Clichy, France.ORCID 0000-0002-3243-6699
Lucas RaynaudService de Radiologie, Hôpital Beaujon, APHP Nord, Clichy & Université de Paris, 92210 Clichy, France.
Frederic DeschampsDepartment of Interventional Radiology, Gustave Roussy Cancer Center, 114 rue Edouard Vaillant, 94805 Villejuif, France.
Gontran VersetGastroentérologie Médicale, Hôpital Erasme, Université Libre de Bruxelles, 1070 Brussels, Belgium.
Hôpital Beaujon · FRInstitut Gustave Roussy · FRUniversité Libre de Bruxelles · BECentre Hospitalier Universitaire de Lille · FRCentre Hospitalier Universitaire de Nice · FRUniversité de Montpellier · FRUniversité Paris-Saclay · FR

Funding

Terumo NCT03053596
6 · The paper itself

Abstract

BACKGROUND AND

aimTransarterial chemoembolization with drug-eluting microspheres (DEM-TACE) is recommended for patients with BCLC stage B hepatocellular carcinoma (HCC) and stage 0-A unsuitable for curative treatments. We assessed efficacy and safety along with hepatobiliary toxicities (HBT) of DEM-TACE using a novel microsphere, LifePearl MATERIALS AND

methods97 patients diagnosed with HCC were prospectively enrolled and treated using LifePearl

resultsAdverse events (AE) were reported in 73.2% of patients, majority being Grade 1-2. Grade ≥ 3 AE reported in 13.4% of patients were mainly related to postembolization syndrome. HBT were observed after 15.5% (29/187) of the DEM-TACEs. Objective response and disease control rates were 81% and 99%, respectively, as the best responses. Survival rates at one and two years were 81% and 66%, respectively, while the median overall survival (OS) was not reached. Median progression free survival was 13.7 months (95% CI: 11.3; 15.6) and median time to TACE untreatable progression was 16.7 months (95% CI: 12.7; not estimable (n.e.)).

conclusionsDEM-TACE using LifePearl

Indexed as

DEM-TACEdoxorubicinhepatobiliary toxicitieshepatocellular carcinomaidarubicin

Identifiers

PMID33212917
PMCPMC7698357
OpenAlexW3103558927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.