Evidence map›Paper›PMID 33212876›Full record

ArticleMolecules (Basel, Switzerland)2020

Design, Synthesis, and Biological Evaluation of Pyridazinones Containing the (2-Fluorophenyl) Piperazine Moiety as Selective MAO-B Inhibitors.

Muhammed Çeçen, Jong Min Oh, Zeynep Özdemir, Saliha Ebru Büyüktuncel, Mehtap Uysal, Mohamed A Abdelgawad, Arafa Musa, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew and 1 more

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Pyridazinone: Current Progress in Synthesis of its Derivatives and Biological Activity.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 6 countries.

Muhammed ÇeçenDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, Malatya 44280, Turkey.
Jong Min OhDepartment of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.
Zeynep ÖzdemirDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Inonu University, Malatya 44280, Turkey.ORCID 0000-0003-4559-2305
Saliha Ebru BüyüktuncelDepartment of Analytical Chemistry, Faculty of Pharmacy, Inonu University, Malatya 44280, Turkey.
Mehtap UysalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Gazi University, Ankara 06100, Turkey.
Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia.
Arafa MusaDepartment of Pharmacognosy, College of Pharmacy, Jouf University, Sakaka 72341, Al Jouf, Saudi Arabia.
Nicola GambacortaDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.
Orazio NicolottiDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari "Aldo Moro", Via E. Orabona, 4, I-70125 Bari, Italy.ORCID 0000-0001-6533-5539
Bijo MathewDepartment of Pharmaceutical Chemistry, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Amrita Health Science Campus, Kochi 682 041, India.
Hoon KimDepartment of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Korea.ORCID 0000-0002-7203-3712
Inonu University · TRSunchon National University · KRUniversity of Bari Aldo Moro · ITAl-Azhar University · EGAmrita Vishwa Vidyapeetham · INBeni-Suef University · EGGazi University · TR

Funding

National Research Foundation of Korea (NRF) NRF-2019R1A2C1088967
6 · The paper itself

Abstract

Twelve pyridazinones (

Indexed as

Drug DesignAnimalsCarbon-13 Magnetic Resonance SpectroscopyCell DeathCell LineCell SurvivalKineticsMiceMolecular Docking SimulationMonoamine OxidaseMonoamine Oxidase InhibitorsPiperazineProton Magnetic Resonance SpectroscopyPyridazinesRecombinant ProteinsMonoamine OxidaseMonoamine Oxidase InhibitorsPiperazinePyridazinesRecombinant ProteinsADMEkineticsmolecular dockingmonoamine oxidasepyridazinonereversibility

Identifiers

PMID33212876
PMCPMC7698448
OpenAlexW3100059036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.