Evidence map›Paper›PMID 33212844›Full record

ArticleJournal of cardiovascular development and disease2020

A Bioengineered Neuregulin-Hydrogel Therapy Reduces Scar Size and Enhances Post-Infarct Ventricular Contractility in an Ovine Large Animal Model.

Jeffrey E Cohen, Andrew B Goldstone, Hanjay Wang, Brendan P Purcell, Yasuhiro Shudo, John W MacArthur, Amanda N Steele, Michael J Paulsen, Bryan B Edwards, Chiaka N Aribeana and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular development and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Navigating the Crossroads of Cell Therapy and Natural Heart Regeneration.Frontiers in cell and developmental biology · 2021
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Jeffrey E CohenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Andrew B GoldstoneDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Hanjay WangDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-2367-5591
Brendan P PurcellDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Yasuhiro ShudoDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
John W MacArthurDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Amanda N SteeleDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Michael J PaulsenDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-1730-0678
Bryan B EdwardsDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Chiaka N AribeanaDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Nicholas C CheungDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Jason A BurdickDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Y Joseph WooDepartment of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305, USA.
Stanford University · USUniversity of Pennsylvania · US

Funding

NIH HHS R01HL089315-7
6 · The paper itself

Abstract

The clinical efficacy of neuregulin (NRG) in the treatment of heart failure is hindered by off-target exposure due to systemic delivery. We previously encapsulated neuregulin in a hydrogel (HG) for targeted and sustained myocardial delivery, demonstrating significant induction of cardiomyocyte proliferation and preservation of post-infarct cardiac function in a murine myocardial infarction (MI) model. Here, we performed a focused evaluation of our hydrogel-encapsulated neuregulin (NRG-HG) therapy's potential to enhance cardiac function in an ovine large animal MI model. Adult male Dorset sheep (

Indexed as

hydrogelischemic heart failuremyocardial infarctionneuregulin

Identifiers

PMID33212844
PMCPMC7711763
OpenAlexW3103898796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.