Evidence map›Paper›PMID 33212793›Full record

ArticleDiagnostics (Basel, Switzerland)2020

A Deep Learning-Based Automated CT Segmentation of Prostate Cancer Anatomy for Radiation Therapy Planning-A Retrospective Multicenter Study.

Timo Kiljunen, Saad Akram, Jarkko Niemelä, Eliisa Löyttyniemi, Jan Seppälä, Janne Heikkilä, Kristiina Vuolukka, Okko-Sakari Kääriäinen, Vesa-Pekka Heikkilä, Kaisa Lehtiö and 16 more

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 71 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Timo KiljunenDocrates Cancer Center, Saukonpaadenranta 2, FI-00180 Helsinki, Finland.
Saad AkramMVision Ai, c/o Terkko Health hub, Haartmaninkatu 4, FI-00290 Helsinki, Finland.ORCID 0000-0002-2570-5870
Jarkko NiemeläMVision Ai, c/o Terkko Health hub, Haartmaninkatu 4, FI-00290 Helsinki, Finland.
Eliisa LöyttyniemiDepartment of Biostatistics, University of Turku, Kiinamyllynkatu 10, FI-20014 Turku, Finland.
Jan SeppäläKuopio University Hospital, Center of Oncology, Kelkkailijantie 7, FI-70210 Kuopio, Finland.ORCID 0000-0002-0922-329X
Janne HeikkiläKuopio University Hospital, Center of Oncology, Kelkkailijantie 7, FI-70210 Kuopio, Finland.
Kristiina VuolukkaKuopio University Hospital, Center of Oncology, Kelkkailijantie 7, FI-70210 Kuopio, Finland.
Okko-Sakari KääriäinenKuopio University Hospital, Center of Oncology, Kelkkailijantie 7, FI-70210 Kuopio, Finland.ORCID 0000-0002-2905-6310
Vesa-Pekka HeikkiläOulu University Hospital, Department of Oncology and Radiotherapy, Kajaanintie 50, FI-90220 Oulu, Finland.
Kaisa LehtiöOulu University Hospital, Department of Oncology and Radiotherapy, Kajaanintie 50, FI-90220 Oulu, Finland.
Juha NikkinenOulu University Hospital, Department of Oncology and Radiotherapy, Kajaanintie 50, FI-90220 Oulu, Finland.
Eduard GershkevitshNorth Estonia Medical Centre, J. Sütiste tee 19, 13419 Tallinn, Estonia.
Anni BorkvelNorth Estonia Medical Centre, J. Sütiste tee 19, 13419 Tallinn, Estonia.
Merve AdamsonNorth Estonia Medical Centre, J. Sütiste tee 19, 13419 Tallinn, Estonia.
Daniil ZolotuhhinNorth Estonia Medical Centre, J. Sütiste tee 19, 13419 Tallinn, Estonia.
Kati KolkNorth Estonia Medical Centre, J. Sütiste tee 19, 13419 Tallinn, Estonia.
Eric Pei Ping PangNational Cancer Centre Singapore, Division of Radiation Oncology, 11 Hospital Crescent, Singapore 169610, Singapore.ORCID 0000-0001-7930-926X
Jeffrey Kit Loong TuanNational Cancer Centre Singapore, Division of Radiation Oncology, 11 Hospital Crescent, Singapore 169610, Singapore.ORCID 0000-0002-4353-8439
Zubin MasterNational Cancer Centre Singapore, Division of Radiation Oncology, 11 Hospital Crescent, Singapore 169610, Singapore.
Melvin Lee Kiang ChuaNational Cancer Centre Singapore, Division of Radiation Oncology, 11 Hospital Crescent, Singapore 169610, Singapore.ORCID 0000-0002-1648-1473
Timo JoensuuDocrates Cancer Center, Saukonpaadenranta 2, FI-00180 Helsinki, Finland.ORCID 0000-0002-0455-8031
Juha KononenDocrates Cancer Center, Saukonpaadenranta 2, FI-00180 Helsinki, Finland.
Mikko MyllykangasDocrates Cancer Center, Saukonpaadenranta 2, FI-00180 Helsinki, Finland.
Maigo RienerDocrates Cancer Center, Saukonpaadenranta 2, FI-00180 Helsinki, Finland.
Miia MokkaTurku University Hospital, Department of Oncology and Radiotherapy, Hämeentie 11, FI-20521 Turku, Finland.
Jani KeyriläinenTurku University Hospital, Department of Oncology and Radiotherapy, Hämeentie 11, FI-20521 Turku, Finland.
Docrates Cancer Center · FINorth Estonia Medical Centre · EEKuopio University Hospital · FIOulu University Hospital · FIDuke-NUS Medical School · SGNational Cancer Centre Singapore · SGTurku University Hospital · FIUniversity of Turku · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A commercial deep learning (DL)-based automated segmentation tool (AST) for computed tomography (CT) is evaluated for accuracy and efficiency gain within prostate cancer patients. Thirty patients from six clinics were reviewed with manual- (MC), automated- (AC) and automated and edited (AEC) contouring methods. In the AEC group, created contours (prostate, seminal vesicles, bladder, rectum, femoral heads and penile bulb) were edited, whereas the MC group included empty datasets for MC. In one clinic, lymph node CTV delineations were evaluated for interobserver variability. Compared to MC, the mean time saved using the AST was 12 min for the whole data set (46%) and 12 min for the lymph node CTV (60%), respectively. The delineation consistency between MC and AEC groups according to the Dice similarity coefficient (DSC) improved from 0.78 to 0.94 for the whole data set and from 0.76 to 0.91 for the lymph nodes. The mean DSCs between MC and AC for all six clinics were 0.82 for prostate, 0.72 for seminal vesicles, 0.93 for bladder, 0.84 for rectum, 0.69 for femoral heads and 0.51 for penile bulb. This study proves that using a general DL-based AST for CT images saves time and improves consistency.

Indexed as

autosegmentationdeep learningprostate cancerradiation therapytreatment planning

Identifiers

PMID33212793
PMCPMC7697786
OpenAlexW3099251286

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.