Evidence map›Paper›PMID 33212780›Full record

Trial reportNutrients2020

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study.

Mercedes Del Río-Moreno, Raúl M Luque, Oriol A Rangel-Zúñiga, Emilia Alors-Pérez, Juan F Alcalá-Diaz, Irene Roncero-Ramos, Antonio Camargo, Manuel D Gahete, José López-Miranda, Justo P Castaño

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mercedes Del Río-MorenoMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Raúl M LuqueMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.ORCID 0000-0002-7585-1913
Oriol A Rangel-ZúñigaMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Emilia Alors-PérezMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Juan F Alcalá-DiazMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Irene Roncero-RamosMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Antonio CamargoMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.
Manuel D GaheteMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.ORCID 0000-0002-4578-2179
José López-MirandaMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.ORCID 0000-0002-8844-0718
Justo P CastañoMaimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain.ORCID 0000-0002-3145-7287
Instituto Maimónides de Investigación Biomédica de Córdoba · ES

Funding

Instituto de Salud Carlos III CP15/00156Instituto de Salud Carlos III PI16/00264Instituto de Salud Carlos III PI17/002287Instituto de Salud Carlos III PIE14/00005Instituto de Salud Carlos III PIE14/00031Junta de Andalucía BIO-0139Junta de Andalucía CTS-1406Junta de Andalucía CTS-525Junta de Andalucía CVI-7450Junta de Andalucía PI-0541-2013Ministerio de Economía, Industria y Competitividad, Gobierno de España AGL2012/39615Ministerio de Economía, Industria y Competitividad, Gobierno de España AGL2015-67896-PMinisterio de Economía, Industria y Competitividad, Gobierno de España BFU2016-80360-RMinisterio de Economía, Industria y Competitividad, Gobierno de España PI13/00023Ministerio de Economía, Industria y Competitividad, Gobierno de España TIN2017-83445-P
6 · The paper itself

Abstract

Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Thus, the aim of this work was to evaluate the influence of 3-year dietary intervention in the expression pattern of the splicing machinery components in peripheral blood mononuclear cells (PBMCs) from patients within the CORDIOPREV study. Expression of splicing machinery components was determined in PBMCs, at baseline and after 3 years of follow-up, from all patients who developed T2DM (Incident-T2DM,

Indexed as

Diet, Fat-RestrictedDiet, MediterraneanRNA SplicingAdultAgedCardiovascular DiseasesDiabetes Mellitus, Type 2FemaleGlucose Tolerance TestGlycated HemoglobinHumansLeukocytes, MononuclearMaleMiddle AgedProspective StudiesYoung AdultGlycated HemoglobinLow-Fat dietMediterranean dietperipheral blood mononuclear cells (PBMCs)splicing machineryType-2 diabetes mellitus

Identifiers

PMID33212780
PMCPMC7696699
OpenAlexW3102473624

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.