Evidence map›Paper›PMID 33212316›Full record

ReviewJournal of neuroimmunology2021

SARS-CoV-2 and nervous system: From pathogenesis to clinical manifestation.

Kiandokht Keyhanian, Raffaella Pizzolato Umeton, Babak Mohit, Vahid Davoudi, Fatemeh Hajighasemi, Mehdi Ghasemi

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neuroimmunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 144 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Musculoskeletal Symptoms and Post-COVID Functional Status among COVID-19 Survivors: A Single-Center Prospective Observational Study.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Changes in cerebral glucose metabolism among mild long COVID patients: an [18F]FDG PET/CT study.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024
    Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Kiandokht KeyhanianDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Raffaella Pizzolato UmetonDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Babak MohitSleep Disorders Center, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Vahid DavoudiAnn Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Fatemeh HajighasemiDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Mehdi GhasemiDepartment of Neurology, University of Massachusetts Medical School, Worcester, MA 01655, USA. Electronic address: mehdi.ghasemi@umassmemorial.org.
University of Massachusetts Chan Medical School · USBrigham and Women's Hospital · USMassachusetts General Hospital · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a growing body of evidence indicates that besides common COVID-19 symptoms, patients may develop various neurological manifestations affecting both the central and peripheral nervous systems as well as skeletal muscles. These manifestations can occur prior, during and even after the onset of COVID-19 general symptoms. In this Review, we discuss the possible neuroimmunological mechanisms underlying the nervous system and skeletal muscle involvement, and viral triggered neuroimmunological conditions associated with SARS-CoV-2, as well as therapeutic approaches that have been considered for these specific complications worldwide.

Indexed as

Coronavirus disease 2019 (COVID-19)EncephalitisGuillain-Barré syndromesMyelitisNeuroimmunitySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

Identifiers

PMID33212316
PMCPMC7647896
OpenAlexW3096686601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.