ArticleContemporary clinical trials2021
Using digital technologies in clinical trials: Current and future applications.
Article in Contemporary clinical trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Digital Health Technologies for Diabetic Foot Ulcers: A Systematic Review of Clinical Evidence, Access Inequities, and Public Health Integration.International journal of environmental research and public health · 2025Pooled it
- Participation of Women in Cardiovascular Trials From 2017 to 2023: A Systematic Review.JAMA network open · 2025Pooled it
- Improving Participant Recruitment in Clinical Trials: Comparative Analysis of Innovative Digital Platforms.Journal of medical Internet research · 2024Pooled it
- Recommendations to promote equity, diversity and inclusion in decentralized clinical trials.Nature medicine · 2024Guideline
- Use of routine healthcare data in randomised implementation trials: a methodological mixed-methods systematic review.Implementation science : IS · 2023Pooled it
- Feasibility of Decentralised Response-Guided Albuminuria Monitoring to Optimise Empagliflozin and Finerenone Therapy in Type 2 Diabetes and Chronic Kidney Disease.Diabetes, obesity & metabolism · 2026Trial
- INTERSTAARS: Attention training for infants with elevated likelihood of developing ADHD: A proof-of-concept randomised controlled trial.Translational psychiatry · 2021Trial
- Usability and Workflow Integration of a Machine Learning-Derived Neonatal Risk Predictor in Kenyan Neonatal Units: Multisite User-Centered Pilot Evaluation.JMIR human factors · 2026Article
- MediaPipe-Based Activity Analysis by Healthcare Professionals: Method Development and Technology Acceptance-A Pilot Study.Sensors (Basel, Switzerland) · 2026Article
- Patient Experiences of Digital Technology Use in Interstitial Lung Disease (PRODIGY-ILD Study): Qualitative Study Using Reflexive Thematic Analysis.JMIR human factors · 2026Observational
- Patients' Perspectives and Experiences of Participating in Anesthesia Research: A Qualitative Study.Anesthesia and analgesia · 2026Article
- Who gets included? Equity in digital and decentralised mental health and neurodevelopmental trials: A systematic review.PLOS digital health · 2026Article
- Child and adolescent psychiatry: challenges, solutions, opportunities, and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026Article
- Shaping the future of clinical trials through strategic foresight.Clinical trials (London, England) · 2026Article
- Global Pharmaceutical Regulation: Comparative Frameworks and Operations.Pharmacy (Basel, Switzerland) · 2026Review
- Frameworks for Guiding the Selection of Digital Data Collection Tools Used in Clinical Trials: Protocol for a Systematic Review.JMIR research protocols · 2026Article
- Participant Experience, Acceptability and Feasibility of Virtual and Digitally Supported Visits in a Phase IIa COPD Trial.Journal of patient experience · 2026Article
- Evolving roles of Data Coordinating Centers in multisite research: Challenges and adaptations from a rapid scoping review.Journal of clinical and translational science · 2026Review
- Article
- Empagliflozin in the Absence of Diabetes: A Systematic Review of Its Anthropometric and Metabolic Effects in Humans and Animals.International journal of endocrinology · 2026Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
In 2015, we provided an overview of the use of digital technologies in clinical trials, both as a methodological tool and as a mechanism to deliver interventions. At that time, there was limited guidance and limited use of digital technologies in clinical research. However, since then smartphones have become ubiquitous and digital health technologies have exploded. This paper provides an update to our earlier publication and an overview of how technology has been used in the past five years in clinical trials, providing examples with varying levels of technological integration and across different health conditions. Digital technology integration ranges from the incorporation of artificial intelligence in diagnostic devices to the use of real-world data (e.g., electronic health records) for study recruitment. Clinical trials can now be conducted entirely virtually, eliminating the need for in-person interaction. Much of the published research demonstrates how digital approaches can improve the design and implementation of clinical trials. While challenges remain, progress over the last five years is encouraging, and barriers can be overcome with careful planning.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.