ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2021
Age-Related Development of Cardiac Remodeling and Dysfunction in Young Black and White Adults: The Coronary Artery Risk Development in Young Adults Study.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Discrepancies in Cardiovascular Disease Risk Perception Among African American Emerging Adults.Nursing (Auckland, N.Z.) · 2025Article
- Latent class analysis of cardiac structure and function and association with premature cardiovascular disease: The Coronary Artery Risk Development in Young Adults (CARDIA) study.American journal of preventive cardiology · 2024Article
- Cumulative effect of metabolic risk factors on left ventricular geometry in those with versus without early-onset type 2 diabetes or prediabetes: The Coronary Artery Risk Development in Young Adults (CARDIA) study.Diabetes, obesity & metabolism · 2024Article
- Blood Pressure in Children in the 21st Century: What Do We Know and Where Do We Go From Here?Hypertension (Dallas, Tex. : 1979) · 2023Review
- Imaging Early Life Cardiovascular Phenotype.Circulation research · 2023Review
- Chronic Kidney Disease, Heart Failure, and Adverse Cardiac Remodeling in Older Adults: The ARIC Study.JACC. Heart failure · 2023Article
- Cardiac Structure and Function Phenogroups and Risk of Incident Heart Failure (from the Multi-ethnic Study of Atherosclerosis).The American journal of cardiology · 2023Article
- The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8.Journal of the American College of Cardiology · 2021Review
- Prognostic Significance of Echocardiographic Measures of Cardiac Remodeling in the Community.Current cardiology reports · 2021Review
- Bending Primordial Trajectories Away From Heart Failure.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- Association of 20-Year Longitudinal Depressive Symptoms With Left Ventricular Geometry Outcomes in the Coronary Artery Risk Development in Young Adults Study: A Role for Androgens?Psychosomatic medicineArticle
- Association of left ventricular diastolic function with coronary artery calcium score: A Project Baseline Health Study.Journal of cardiovascular computed tomographyObservational
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Abstract
backgroundLittle is known about the timing of preclinical heart failure (HF) development, particularly among blacks. The primary aims of this study were to delineate age-related left ventricular (LV) structure and function evolution in a biracial cohort and to test the hypothesis that young-adult LV parameters within normative ranges would be associated with incident stage B-defining LV abnormalities over 25 years, independent of cumulative risk factor burden.
methodsData from the Coronary Artery Risk Development in Young Adults study were analyzed. Participants (n = 2,833) had a mean baseline age of 30.1 years; 45% were black, and 56% were women. Generalized estimating equation logistic regression was used to estimate age-related probabilities of stage B LV abnormalities (remodeling, hypertrophy, or dysfunction) and logistic regression to examine risk factor-adjusted associations between baseline LV parameters and incident abnormalities. Cox regression was used to assess whether baseline LV parameters associated with incident stage B LV abnormalities were also associated with incident clinical (stage C/D) HF events over >25 years' follow-up.
resultsProbabilities of stage B LV abnormalities at ages 25 and 60 years were 10.5% (95% CI, 9.4%-11.8%) and 45.0% (95% CI, 42.0%-48.1%), with significant race-sex disparities (e.g., at age 60, black men 52.7% [95% CI, 44.9%-60.3%], black women 59.4% [95% CI, 53.6%-65.0%], white men 39.1% [95% CI, 33.4%-45.0%], and white women 39.1% [95% CI, 33.9%-44.6%]). Over 25 years, baseline LV end-systolic dimension indexed to height was associated with incident systolic dysfunction (adjusted odds ratio per 1 SD higher, 2.56; 95% CI, 1.87-3.52), eccentric hypertrophy (1.34; 95% CI, 1.02-1.75), concentric hypertrophy (0.69; 95% CI, 0.51-0.91), and concentric remodeling (0.68; 95% CI, 0.58-0.79); baseline LV mass indexed to height
conclusionsStage B LV abnormalities and related racial disparities were present in young adulthood, increased with age, and were associated with baseline variation in indexed LV end-systolic dimension and mass. Baseline indexed LV end-systolic dimension and mass were also associated with incident clinical HF. Efforts to prevent the LV abnormalities underlying clinical HF should start from a young age.
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